Plasma MMP2/TIMP4 Ratio at Follow-up Assessment Predicts Disease Progression of Idiopathic Pulmonary Arterial Hypertension

Lung
Veronika WetzlHenning Gall

Abstract

Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) are of particular interest in the remodeling processes of pulmonary hypertension. The aim of this study was to investigate MMP/TIMP ratios of selected biomarkers (MMP2, MMP9, TIMP1, TIMP4) at follow-up examination (V2) and their prognostic value in patients with idiopathic pulmonary arterial hypertension (iPAH). Blood samples were taken from iPAH patients during right heart catheterization at diagnosis (V1, from 2003 to 2012) and first follow-up examination (V2). MMP2, MMP9, TIMP1, and TIMP4 plasma levels at V2 were determined by ELISA. Coincident with sample collection hemodynamic, laboratory, and clinical parameters were acquired. Additionally, death and clinical worsening (CW) events were listed until July 2015. MMP2/TIMP1 and MMP9/TIMP1 did not correlate with hemodynamic and clinical parameters. MMP2/TIMP4 showed a good correlation with mean pulmonary arterial pressure (mPAP), pulmonary vascular resistance, estimated glomerular filtration rate (eGFR), and tricuspid annular plain systolic excursion (TAPSE). MMP9/TIMP4 shows good correlation with mPAP and eGFR. MMP2/TIMP4 showed significant results in the receiver operating characteristics analysis predict...Continue Reading

References

Nov 29, 1996·The Journal of Biological Chemistry·J GreeneY E Shi
Aug 25, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·M SelmanA Pardo
Apr 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Du JunbaoTang Chaoshu
May 10, 2005·American Journal of Respiratory and Critical Care Medicine·Ralph Theo SchermulyWerner Seeger
Aug 5, 2006·American Journal of Respiratory and Critical Care Medicine·Paul R ForfiaPaul M Hassoun
Aug 22, 2006·European Journal of Clinical Investigation·G GiannelliS Antonaci
Apr 5, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·M MullerP Y Benhamou
Oct 8, 2009·Journal of Pharmacological Sciences·Muneyoshi OkadaYukio Hara
Dec 22, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jagdish HiremathUNKNOWN TRUST Study Group
Jun 10, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Christian SchumannFrank Kramer
Jun 16, 2010·International Journal of Cardiology·Victoria PolyakovaSawa Kostin
Jun 1, 2011·Journal of Cardiac Failure·Robin A P WeirLeong L Ng
Sep 20, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yanhui WangDe-an Guo
Nov 22, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Natia QipshidzeSuresh C Tyagi
Aug 15, 2012·Experimental Biology and Medicine·Jing HuangRajamma Mathew
Jun 25, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ting-Yen ChiangChao-Bin Yeh
Dec 18, 2013·International Journal of Molecular Medicine·Yang BaiHuai-Liang Wang
Jun 16, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Caroline MorinSamuel Fortin
Jul 6, 2014·The European Respiratory Journal·Rekha ChaudhuriNeil C Thomson
Jul 19, 2014·The European Respiratory Journal·Mark-Jan PloegstraRolf M F Berger
Aug 31, 2016·International Journal of Cardiology·Svenja L TiedeHenning Gall

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Citations

Nov 2, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Nobuhiro KikuchiHiroaki Shimokawa
Aug 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Georg Daniel DuerrSe-Chan Kim
Jan 10, 2021·International Journal of Molecular Sciences·Griselda A Cabral-PachecoMargarita L Martinez-Fierro
Jun 5, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Michal SchäferMichael E Yeager

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