PMID: 11316119Apr 24, 2001Paper

Plasma monocyte chemoattractant protein-1 antigen levels and the risk of restenosis after coronary stent implantation

Japanese Circulation Journal
S OshimaH Yasue

Abstract

Monocyte chemoattractant protein-1 (MCP-1) plays a fundamental role in monocyte recruitment and has been implicated in atherosclerosis. The present study tested the hypothesis that increased levels of MCP-1 are associated with an increased risk for restenosis post stent implantation. The plasma MCP-1 antigen levels were measured pre-stenting, and at 24 and 48 h and 6 months post stenting in 41 patients with stable exertional angina (SEA) who had undergone successful stent implantation. Nineteen patients with chest pain syndrome were selected as a control group. Initial plasma MCP-1 antigen levels (mean +/- SE, pg/ml) in the patients with SEA were significantly higher than those in the control group (852.3+/-51.4 vs 418.2+/-26.7, p<0.001). The patients with SEA were divided into 2 groups based on follow-up angiographic findings: 17 patients with restenosis (R group); 24 patients without restenosis (N group). The lesion was significantly longer in the R group than in the N group (p<0.03). Plasma MCP-1 antigen levels at pre-stenting were not significantly different between the 2 groups (820.6+/-69.1 in the R group vs 874.7+/-73.8 in the N group). Serial changes of plasma MCP-1 levels were plotted as percent changes from the initia...Continue Reading

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Citations

Feb 3, 2012·Biomarkers in Medicine·Jacco C KarperPaul H A Quax
Mar 3, 2009·Biological Research for Nursing·Lorraine FrazierEric Boerwinkle
Oct 17, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Tadashi FujiwaraTakehito Takada
Jan 10, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Tianshu ZhangJun Amano
Oct 28, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Akira KawamuraKeijiro Saku
Jan 28, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Takayuki TanakaYoshifusa Aizawa
Jul 1, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Kengo Fukushima KusanoTohru Ohe
Jul 1, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroaki KawanoKatsusuke Yano
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