Plasma NEFA storage in adipose tissue in the postprandial state: sex-related and regional differences.

Diabetologia
Christina KoutsariMichael D Jensen

Abstract

We recently reported that a small fraction of circulating NEFA is stored through direct uptake in subcutaneous fat in postabsorptive humans in vivo and that this pathway may favour lower-body fat distribution in women. Here, we examined sex-related and regional differences in storage of plasma NEFA in subcutaneous adipose tissue during postprandial conditions. At 1 h after lunch, men and women of normal weight received an intravenous bolus of approximately 1.66 MBq [1-(14)C]oleate followed by timed subcutaneous fat biopsies. The preceding breakfast was either a normal- or high-fat meal; the high-fat breakfast was used to create postprandial oleate concentrations in the postabsorptive range. Storage of the NEFA tracer in adipose tissue (dpm/g lipid) was greater in women; in both sexes abdominal fat stored tracer more avidly than femoral fat. A greater fraction of the administered tracer was stored in whole body subcutaneous fat of women than in that of men (27 +/- 3 vs 8 +/- 1%, respectively, p < 0.0001). No significant differences in tracer storage were observed between participants consuming the high- vs normal-fat breakfast. Postprandial NEFA storage in subcutaneous fat through direct uptake accounts for approximately 25% of ...Continue Reading

References

Nov 1, 1990·Annals of Clinical Biochemistry·S M HumphreysK N Frayn
Sep 1, 1971·The American Journal of Physiology·M Di GirolamoJ W Fertig
Feb 1, 1995·The American Journal of Clinical Nutrition·M D JensenP F Sheedy
Dec 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·F K WeltyE J Schaefer
Feb 26, 2003·The American Journal of Clinical Nutrition·Bettina MittendorferSamuel Klein
Jun 5, 2003·Journal of Lipid Research·Yourka D TchoukalovaMichael D Jensen
Jan 29, 1961·Biochimica Et Biophysica Acta·S KERPELB SHAPIRO
Oct 1, 1961·The Journal of Clinical Investigation·S J FRIEDBERGE H ESTES
Oct 28, 2004·American Journal of Physiology. Endocrinology and Metabolism·Ana Paola UrangaMichael Jensen
Jun 29, 2006·American Journal of Physiology. Endocrinology and Metabolism·Susanne B Votruba, Michael D Jensen

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Citations

Jan 13, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K N ManolopoulosK N Frayn
Feb 17, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K L GroveD J Clegg
Sep 13, 2012·American Journal of Physiology. Endocrinology and Metabolism·Jason M NgDavid E Kelley
Feb 18, 2012·American Journal of Physiology. Endocrinology and Metabolism·Susanne B Votruba, Michael D Jensen
Dec 1, 2010·Journal of Lipid Research·Carolyn C AllredMichael D Jensen
May 21, 2010·The Journal of Clinical Endocrinology and Metabolism·Sarah Rosner PreisCaroline S Fox
Apr 25, 2013·PloS One·Luisa GilardiniCecilia Invitti
Oct 31, 2015·International Journal of Molecular Sciences·Marta Izabela JonasMonika Puzianowska-Kuznicka
May 26, 2009·Progress in Lipid Research·Max Lafontan, Dominique Langin
Mar 10, 2009·Diabetes/metabolism Research and Reviews
May 21, 2013·Biochimica Et Biophysica Acta·Ursula A White, Yourka D Tchoukalova
Jul 3, 2009·Metabolism: Clinical and Experimental·Baqiyyah ConwayTrevor J Orchard
Nov 5, 2014·Nature Reviews. Endocrinology·Fredrik Karpe, Katherine E Pinnick
Jun 17, 2011·The Journal of Physical Chemistry. a·D ColognesiM Fichtner
Apr 24, 2019·American Journal of Physiology. Endocrinology and Metabolism·Yanli CaoMichael D Jensen
Jul 26, 2019·The Proceedings of the Nutrition Society·Alan Fappi, Bettina Mittendorfer
Sep 6, 2014·The Journal of Clinical Endocrinology and Metabolism·Manpreet S MundiMichael D Jensen
Oct 22, 2014·The American Journal of Clinical Nutrition·Martin TorrianiMiriam A Bredella
Aug 24, 2017·Cadernos de saúde pública·Maria Auxiliadora Nogueira SaadRubens Antunes da Cruz
Apr 16, 2020·International Journal of Molecular Sciences·Lucas Opazo-RíosJesús Egido
Feb 20, 2021·Primary Care Diabetes·Hooman EbrahimiSedighe Moradi
Feb 4, 2021·Menopause : the Journal of the North American Menopause Society·Aaron DehghanFredrik Karpe

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