PMID: 8582385Sep 1, 1995Paper

Plasma neuro-endocrine activity in very elderly subjects and patients with and without heart failure

European Heart Journal
D P DutkaJ G Cleland

Abstract

Marked neuro-endocrine activation in patients with heart failure indicates a worse prognosis and a greater prognostic benefit from the use of ACE inhibitors. However, although the incidence of heart failure rises rapidly with age, relatively little is known about activation of the renin-angiotensin and sympathetic nervous system in patients with heart failure over the age of 75 years. This study was undertaken to investigate plasma concentrations of neurohormonal variables in elderly patients referred to the cardiac clinic with a presumptive, but unconfirmed, diagnosis of heart failure, and to compare these values to plasma concentrations found in age-matched normal subjects. Fifty patients referred with a diagnosis of heart failure were studied. All were receiving a diuretic but not an ACE inhibitor. Patients with renal, haematological and valve disease were excluded. Routine biochemistry and neurohormonal measurements were performed at their first visit, together with an electrocardiogram, chest X-ray and a full clinical examination by an experienced cardiologist. An echocardiogram and Doppler study was also performed and the diagnosis of heart failure either confirmed or refuted. Plasma concentrations of neuro-endocrine vari...Continue Reading

Citations

Aug 7, 1998·Journal of Psychopharmacology·C B Kelly, S J Cooper
Jun 17, 2011·Journal of the American College of Nutrition·Karl T WeberWilliam L Hickerson
Mar 15, 2011·European Heart Journal·Brian J BorkowskiKarl T Weber
Mar 12, 2004·European Journal of Heart Failure·Andreas KjaerClaus Leth Petersen
Feb 1, 2003·European Journal of Heart Failure·Dave J W van KraaijWillibrord H L Hoefnagels
Apr 23, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·R WillenbrockR Dietz

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