PMID: 8592643Sep 29, 1995Paper

Plasma neuropeptide Y is reduced in patients with Alzheimer's disease

Neuroscience Letters
S KoideS Yamagami

Abstract

Neuropeptide Y (NPY) is demonstrated to be involved in the pathophysiology of Alzheimer's disease, as well as somatostatin. We measured the plasma NPY content in patients with Alzheimer's disease and healthy control subjects (n = 25) by HPLC coupled with radioimmunoassay. The difference in screening pattern of NPY-like immunoreactivity in 50 fractions eluted by HPLC obtained from the plasma peptide-rich fraction between patients with Alzheimer's disease and healthy controls suggested the abnormal metabolism of plasma NPY in patients with Alzheimer's disease. Plasma NPY in patients with Alzheimer's disease was significantly decreased compared with that in healthy controls, which was compatible with the findings obtained from the brain and cerebrospinal fluid and could be involved in the pathogenesis or pathophysiology of Alzheimer's disease.

References

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May 1, 1993·Arthritis and Rheumatism·A Akesson, R Ekman

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Citations

Nov 12, 2013·Neuropeptides·Eva BorbélyZsuzsanna Helyes
Nov 16, 2001·Journal of Inorganic Biochemistry·J Croom, I L Taylor
Apr 12, 2002·Progress in Neurobiology·François Torreilles, Jacques Touchon
Jul 16, 2014·Canadian Journal of Physiology and Pharmacology·Francesco AngelucciCarlo Caltagirone
Aug 27, 2014·Journal of Chemical Neuroanatomy·D V Hinova-PalovaW Ovtscharoff
Sep 1, 2014·NeuroImage·Arash NazeriUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 25, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Huixian YeZhonghong Gao
May 26, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Caterina ProtoAntonio Lanzone
Sep 5, 2019·Frontiers in Neuroscience·Chunrong LiKangding Liu
Jan 12, 2021·Journal of Neuroendocrinology·Nicola J Lee, Herbert Herzog
Jul 25, 2021·International Journal of Molecular Sciences·Chiara MagriMassimo Gennarelli
Dec 16, 2020·Inorganic Chemistry·Shira Ben-Shushan, Yifat Miller

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