Plasma neurotransmitters and functional illness

Psychotherapy and Psychosomatics
F LechinM E Lechin

Abstract

Although the concept of functional illness has blurred boundaries, some consensus exists on its understanding among clinicians. In short, it is easier to conceive than to define functional illness. Semantic and conceptual discussion concerning this issue have been endless. Many links exist that connect brain and body (mind and organs, psyche and soma). Amongst them, neurotransmitters, released by peripheral neurons and some glandular cells (adrenal, enterochromaffin cells, mast cells), are diverted into the bloodstream. Although neurotransmitters cannot cross the blood-brain barrier, basic and clinical research has progressively established the relationship between central and peripheral neurochemical activities. Hence, it is possible to obtain some approach to the central profile through the measurement of circulating neurotransmitters. However, this approach is more reliable if we can measure all circulating factors and, in addition, test the responses to different kinds of challenges (stressors, drugs, etc.). All diseases (somatic, psychiatric and psychosomatic) present some kind of plasma neurotransmitter disturbance; however, only in some has the whole abnormal profile been established. Technical difficulties as well as ex...Continue Reading

Citations

May 21, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Fuad Lechin, Bertha van der Dijs
Jun 6, 2003·Applied Neuropsychology·Elizabeth A AttreeChristine Wilson
Aug 11, 2010·Neuroscience and Biobehavioral Reviews·David T MarcKelly L Olson
Jul 11, 2013·American Journal of Therapeutics·Fuad LechinBetty Pardey-Maldonado
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fuad LechinDenisa Zlacka
Jan 9, 2021·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Neetu SharmaBrij Sharma

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