Abstract
Acute heart failure (AHF) is frequently associated with worsening renal function in adult patients. Neutrophil gelatinase-associated lipocalin (NGAL) serves as an early marker for acute renal tubular injury. To assess the role of plasma NGAL in predicting worsening renal function (WRF) in children with AHF, we studied 30 children hospitalized for AHF; children with history of chronic renal disease or on nephrotoxic drugs were excluded. Twenty age- and sex-matched healthy children were included in the study as a control group. Echocardiographic examination was performed on admission. Blood urea nitrogen (BUN), serum creatinine, estimated glomerular filtration rate (eGFR) and plasma NGAL levels were measured on admission and 72 h later. Seventeen (56.6%) patients developed WRF within the three-day follow-up period. At presentation, plasma NGAL level was significantly elevated in children who developed WRF. Admission plasma NGAL level correlated with renal parameters (BUN, creatinine and eGFR) as well as with left ventricular systolic parameters (ejection fraction and fractional shortening). For prediction of WRF, admission plasma, NGAL level>27.5 μg/L had sensitivity and specificity of 90% and 68%, respectively. The area under th...Continue Reading
References
Nov 4, 2000·Biochimica Et Biophysica Acta·S Xu, P Venge
Jan 19, 2007·Journal of the American Society of Nephrology : JASN·Kai M Schmidt-OttJonathan Barasch
Feb 19, 2008·European Journal of Heart Failure·Marco MetraLivio Dei Cas
Sep 23, 2008·European Journal of Heart Failure·Kevin DammanHans L Hillege
Jan 30, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Davide BolignanoMichele Buemi
Feb 14, 2009·Journal of the American College of Cardiology·Wilfried MullensW H Wilson Tang
Feb 4, 2010·Journal of Cardiac Failure·Arash AghelW H Wilson Tang
May 8, 2010·Journal of the American College of Cardiology·Michael HaaseAnja Haase-Fielitz
Aug 6, 2010·European Journal of Heart Failure·Kevin DammanUNKNOWN CIBIS-2 Investigators and Committees
Dec 1, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Margarida AlvelosPaulo Bettencourt
Jan 21, 2011·The American Journal of Cardiology·Tobias BreidthardtChristian Mueller
Jun 1, 2011·Journal of Cardiac Failure·Kevin ShresthaW H Wilson Tang
Jan 10, 2012·Critical Care : the Official Journal of the Critical Care Forum·Tobias BreidthardtChristian Mueller
Feb 22, 2012·BMC Cardiovascular Disorders·Stephen MacdonaldXiao-Fang Xu
May 23, 2012·European Heart Journal·John J V McMurrayUNKNOWN ESC Committee for Practice Guidelines
Jun 27, 2012·European Journal of Heart Failure·Sean P CollinsAlan B Storrow
Citations
Oct 13, 2016·Frontiers in Physiology·Anastasia AsimakopoulouRalf Weiskirchen
Feb 21, 2019·BMJ Open·Dominique Dos ReisCarlos El Khoury
Jun 16, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Luís Taddeo FilhoMaria Inês da Rosa
Jan 5, 2021·International Urology and Nephrology·Simge AcarMehmet Kanbay