Plasma Neutrophil Gelatinase-Associated Lipocalin as a Marker of Tubular Damage in Diabetic Nephropathy

Annals of Laboratory Medicine
So Young KimWon Ki Min

Abstract

An increase in neutrophil gelatinase-associated lipocalin (NGAL) indicates tubular injury. Diabetic nephropathy causes typical changes in the kidney, characterized by glomerulosclerosis and eventual tubular damage. We validated the usefulness of plasma NGAL (pNGAL) as a biomarker of tubular damage in patients with diabetic nephropathy. We included 376 patients with diabetes mellitus (260 patients with chronic renal insufficiency who had not received hemodialysis and 116 hemodialyzed due to diabetic nephropathy) and 24 healthy controls. Patients with chronic renal insufficiency were divided into three groups according to urinary albumin excretion (UAE) levels. pNGAL levels were measured using the Triage NGAL test (Alere, San Diego, CA, USA) and were compared between groups. We also examined whether pNGAL level was related to the degree of albuminuria and cystatin C-based glomerular filtration rate (GFR). Mean pNGAL levels of the healthy controls, chronic renal insufficiency patients with diabetes mellitus, and hemodialyzed patients were 61.9±5.3 ng/mL, 93.4±71.8 ng/mL, and 1,536.9±554.9 ng/mL, respectively. pNGAL level increased significantly in patients with severe albuminuria (P<0.001) and had a moderate correlation with the d...Continue Reading

References

Nov 13, 2003·Current Diabetes Reports·Aled O Phillips
Oct 13, 2005·JAMA : the Journal of the American Medical Association·Patrik FinneCarola Grönhagen-Riska
Aug 30, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Prasad Devarajan
Jan 30, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Davide BolignanoMichele Buemi
Mar 27, 2009·Kidney & Blood Pressure Research·Davide BolignanoMichele Buemi
Jun 25, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Davide BolignanoMichele Buemi

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Citations

Aug 25, 2020·Annals of Laboratory Medicine·Christian AlbertAnja Haase-Fielitz
Oct 4, 2020·Journal of Cellular and Molecular Medicine·Ting-Ting JiShou-Jun Bai
Nov 27, 2019·Molecular Metabolism·Haiyan FuDong Zhou

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

SPSS

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