Plasma neutrophil gelatinase-associated lipocalin levels are associated with the presence and severity of coronary heart disease

PloS One
Chao LiChenliang Pan

Abstract

This study aimed to compare the levels of plasma neutrophil gelatinase-associated lipocalin (NGAL), matrix metalloproteinase (MMP)-9, high-sensitivity C-reactive protein (hs-CRP), and interleukin (IL)-1β across different clinical presentations of coronary artery disease and to evaluate the relationship between those biomarkers and the severity of coronary artery lesions in patients without kidney disease. We examined 365 eligible patients who underwent coronary angiography. A total of 124 ST-segment elevation myocardial infarction (STEMI) patients, 117 stable angina pectoris (SAP) patients and 124 patients without atherosclerotic plaques were enrolled in the study. Plasma NGAL, MMP-9, hs-CRP, and IL-1β were measured in all patients using the enzyme-linked immunosorbent assay (ELISA) method. According to the SYNTAX score, the STEMI patients and SAP patients were divided into another set of 2 groups: a high score group (≥ 33, n = 29) and a low score group (<33, n = 212). The relationship between those biomarkers and the severity of coronary stenosis was examined by Spearman correlation analysis; the ability for NGAL to discriminate severe coronary stenosis was examined by receiver operating characteristic (ROC) curve; the influen...Continue Reading

References

Aug 26, 1998·Journal of the American College of Cardiology·H KaiT Imaizumi
Jul 2, 2003·Circulation·Toshihiko SanoJunichi Yoshikawa
Oct 29, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Anne-Louise HemdahlGöran K Hansson
Sep 22, 2009·The American Journal of Cardiology·Theodoros ZografosDemosthenes Katritsis
Jan 9, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Limin DingYoshifusa Aizawa
Feb 1, 2011·Trends in Cardiovascular Medicine·Masafumi Takahashi
Aug 28, 2012·European Heart Journal·UNKNOWN Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC)Doron Zahger
Sep 19, 2012·International Journal of Inflammation·Nikolaos KafkasKonstantinos Makris
Jul 24, 2018·Clinica Chimica Acta; International Journal of Clinical Chemistry·Setor K KunutsorStephan J L Bakker
Sep 29, 2018·Scandinavian Journal of Clinical and Laboratory Investigation·Zenthuja SivalingamSanne Bøjet Larsen

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Citations

Apr 25, 2020·European Journal of Clinical Investigation·Aldo BonaventuraFabrizio Montecucco

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
coronary artery bypass

Software Mentioned

SPSS

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