PMID: 12751689May 20, 2003Paper

Plasma neutrophil lipocalin, elastase-alpha1-antitrypsin complex and neutrophil protease 4 in preterm infants with respiratory distress syndrome

Scandinavian Journal of Clinical and Laboratory Investigation
T SvegerS Laurin

Abstract

Respiratory distress syndrome (RDS) and chronic lung disease of prematurity (CLD) are associated with inflammation of the airways and interstitial tissue of the lung. It is hypothesized that RDS severity and the risk of developing CLD may be correlated with neutrophil gelatinase-associated lipocalin (NGAL), a marker of leucocyte activity, human elastase-alpha1-antitrypsin complex (HEAT) or free and complexed neutrophil protease 4 (NP4), markers of proteolytic enzyme secretion from granulocytes. Thirty-three preterm infants with RDS were enrolled in the study and plasma sampled between 3 and 14 days of life. NGAL, HEAT and NP4 concentrations varied widely in infants with RDS. Significant correlations between subsequent development of CLD and plasma concentrations of HEAT and NP4, respectively, were found on days 3-4 of life, p=0.006 and p=0.02, respectively.

References

Nov 1, 1995·Scandinavian Journal of Clinical and Laboratory Investigation·L AxelssonK Ohlsson
Dec 11, 1999·European Journal of Pediatrics·C P Speer

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Citations

Oct 21, 2011·Renal Failure·Mike Smertka, Jerzy Chudek
May 30, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Eugenia M CraciunPeter Ruef
Aug 22, 2015·PloS One·John H WenKevin A Glenn
Aug 23, 2016·Clinical Medicine Insights. Pediatrics·Mohammed Farouk M AfifyWaleed Mahamoud Abd El-Hamied
Apr 23, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A M DittrichE Hamelmann

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