PMID: 7539338Jan 1, 1995Paper

Plasma nitrate clearance in mice: modeling of the systemic production of nitrate following the induction of nitric oxide synthesis

Cancer Chemotherapy and Pharmacology
E VeszelovskyB C Baguley

Abstract

Nitric oxide (NO) is produced in mammals by the enzyme NO synthase (NOS) in response to a number of agents, including the experimental antitumour agent flavone acetic acid (FAA) and the cytokine tumour necrosis factor-alpha (TNF). NO is converted rapidly in the presence of oxygen, water and haemoglobin to oxidation products, largely nitrate. To quantitate the production of nitric oxide it is necessary to know the clearance of nitrate. The concentration of nitrite and nitrate ion in the plasma of C3H and BDF1 (C57BL6 x DBA2) mice was assessed before and after injection of sodium nitrate and sodium nitrite. Nitrite was covered rapidly to nitrate and the kinetics of elimination of nitrate were determined. There was no significant difference between results obtained with different mouse strains, between levels of nitrite and nitrate, or between i.p. and i.v. administration, and the observations were therefore combined. The volume of distribution of nitrate was 0.71 +/- 0.04 l/kg and the clearance was 0.32 +/- 0.02 l/h-1/kg-1 (plasma half-life, 1.54 h). Using previously published data, we developed a pharmacokinetic-pharmacodynamic model that relates the production of TNF in response to administration of FAA, the enhancement of NOS ...Continue Reading

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Citations

May 12, 2005·Clinical Biochemistry·Ayşe BalatYavuz Coşkun
Nov 19, 2003·Nitric Oxide : Biology and Chemistry·Anna WickmanKenneth Caidahl
Dec 5, 1998·Free Radical Biology & Medicine·J C ter SteegeW A Buurman
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May 5, 2011·Canadian Journal of Physiology and Pharmacology·Kan HuangWilliam D McCumbee
Oct 23, 2010·Expert Opinion on Investigational Drugs·Bruce C Baguley, Dietmar W Siemann
Jan 25, 2005·Journal of Pharmaceutical Sciences·Abhijit ChakrabortyWilliam J Jusko
May 7, 2009·Oral Microbiology and Immunology·A NemecU Skaleric
Sep 17, 2008·Oral Microbiology and Immunology·A NemecU Skaleric
Mar 21, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F A SehbaJ B Bederson
May 23, 2006·Journal of Paediatrics and Child Health·Ayşe BalatSaime Sahinöz
Apr 9, 2002·European Journal of Ophthalmology·S DoganayH Er
Feb 20, 2019·Journal of Pharmacokinetics and Pharmacodynamics·Felix HeldJohan Gabrielsson
Jun 15, 2017·EFSA Journal·UNKNOWN EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)Maged Younes
Jan 5, 2002·Journal of the American Academy of Dermatology·Cem EverekliogluMustafa Cekmen
Dec 24, 2003·Journal of Agricultural and Food Chemistry·Gow-Chin Yen, Hsi-Huai Lai

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