PMID: 9171967May 1, 1997

Plasma nitric oxide metabolite in women with primary Raynaud's phenomenon and in healthy subjects

Clinical Physiology
A RingqvistA Wennmalm

Abstract

Primary Raynaud's phenomenon (PRP) is characterized by cold- or stress-induced transient attacks of impaired skin circulation in fingers and/or toes. PRP displays seasonal variation with less severe symptoms in the summer. The aetiology has not been clarified. The aims of the present study were (a) to assess the influence of cold exposure on the plasma levels of the nitric oxide (NO) metabolite, nitrate, in patients with PRP and in healthy control subjects; and (b) to investigate whether there is a seasonal variation in these plasma levels. In a group of women with PRP and matched control subjects, venous blood was sampled before and at the end of a 40-min period of whole-body cooling. The study was performed with the same protocol on two occasions; once in the winter and once in the summer. A seasonal variation was detected with higher plasma levels of nitrate in the winter than in the summer, both in PRP and in control subjects. However, the plasma level of nitrate was not changed in response to cold exposure on any occasion, either in the patient or in the control group. Our study indicates that NO formation is up-regulated in response to cold weather in both study groups. However, NO formation does not seem to be increased ...Continue Reading

References

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Citations

Jul 1, 1998·Clinical Biochemistry·G EllisS K Makela
Oct 30, 1998·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·E P TurtonR C Kester
Mar 11, 2010·European Heart Journal·Martin FeelischRichard B Weller
Nov 26, 2005·Annals of the Rheumatic Diseases·E J KingdonK P Moore
Oct 31, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Steve M Helmke, Mark W Duncan
Oct 9, 2002·International Journal of Circumpolar Health·Tiina Pääkkönen, Juhani Leppäluoto

Related Concepts

Cold Temperature
Nitrates
Nitric Oxide
Raynaud Phenomenon
Seasonal Variation
Paired Comparisons

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