Plasma nonesterified Fatty Acid intolerance and hyperglycemia are associated with intravenous lipid-induced impairment of insulin sensitivity and disposition index

The Journal of Clinical Endocrinology and Metabolism
A CarpentierG F Lewis

Abstract

It is currently unclear why susceptibility to lipid-induced impairment of beta-cell function varies in different populations. The aim of the study was to determine whether mild hyperglycemia may be associated with nonesterified fatty acid (NEFA) intolerance and increased iv lipid-induced lipotoxic effect on the beta-cell. The study consisted of an experimental design with control group conducted at an academic clinical research center. Twenty-six overweight or obese individuals (12 with normal glucose tolerance, nine with impaired glucose tolerance or type 2 diabetes, and five subjects who previously had impaired glucose tolerance or type 2 diabetes but at the time of study had normal glucose tolerance after biliopancreatic diversion). We assessed insulin sensitivity (S(I)) and beta-cell function [insulin disposition index (DI)] after an overnight iv infusion of heparin + Intralipid (HI) vs. normal saline for 16 h using a stepwise, incremental iv glucose infusion followed by a hyperglycemic clamp. We measured S(I), DI, HI-induced change in plasma NEFA, and its association with HI-induced change in S(I) and DI. HI resulted in significant reduction in S(I) and DI across the three groups of participants. HI-induced elevation of pl...Continue Reading

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Citations

May 22, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Daniël H van RaalteMichaela Diamant
Jul 8, 2015·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Joseph W GordonJonathan McGavock
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May 12, 2017·PloS One·Matthieu St-JeanMarie-France Hivert
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Jul 1, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Mikael Rydén, Peter Arner
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Dec 16, 2020·Archives of Endocrinology and Metabolism·Valeria Bahdur Chueire, Elza Muscelli
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Jan 26, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Sanjay KalraGanapathi Bantwal
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Apr 20, 2021·American Journal of Physiology. Endocrinology and Metabolism·Émilie MontastierAndré C Carpentier
Mar 3, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Gong Deuk BaeYoon Sin Oh

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