Plasma norepinephrine increased during coronary occlusion in hypertensive pigs that developed ventricular fibrillation

Physiology & Behavior
D A KirbyJ M Pinto

Abstract

Although hypertension is associated with increased risk of sudden cardiac death, the mechanisms involved remain enigmatic. Little is known about hemodynamic and plasma catecholamine concentration changes during coronary artery occlusion in hypertensive subjects. To study this, 30 pigs were implanted with catheters in the aorta and a silk snare around the left anterior descending coronary artery that could later be pulled to permanently occlude the artery. Perinephritic hypertension was induced in 14 of the animals over 3 weeks by wrapping one kidney in silk followed by contralateral nephrectomy. Coronary artery occlusion (CAO) was carried out in all pigs in the conscious resting state. Ventricular fibrillation (VF) developed in 50% of each group within 15 min after coronary artery occlusion. The hypertensive VF group showed an increase in norepinephrine concentration of 112 +/- 46%; a significantly greater increase than the intact VF group, which showed a 29 +/- 7% increase in norepinephrine concentration 5 min after coronary artery occlusion (p < 0.05).

References

Jul 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·B LiangB Lown
Jan 10, 1993·The New England Journal of Medicine·R L ConverseR G Victor
Jan 1, 1990·Clinical and Experimental Hypertension. Part A, Theory and Practice·A JindraJ Bultas
Sep 24, 1987·The New England Journal of Medicine·J M McLenachanH J Dargie
Feb 1, 1973·Analytical Biochemistry·P G Passon, J D Peuler
May 1, 1971·Annals of Internal Medicine·G L Engel
Mar 1, 1962·Circulation Research·D B GORDON, A NOGUEIRA

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.