Plasma Nuclear Magnetic Resonance Metabolomics Discriminates Between High and Low Endoscopic Activity and Predicts Progression in a Prospective Cohort of Patients With Ulcerative Colitis

Journal of Crohn's & Colitis
Fay ProbertDaniel C Anthony

Abstract

Endoscopic assessment of ulcerative colitis [UC] is one of the most accurate measures of disease activity, but frequent endoscopic investigations are disliked by patients and expensive for the healthcare system. A minimally invasive test that provides a surrogate measure of endoscopic activity is required. Plasma nuclear magnetic resonance [NMR] spectra from 40 patients with UC followed prospectively over 6 months were analysed with multivariate statistics. NMR metabolite profiles were compared with endoscopic [Ulcerative Colitis Endoscopic Index of Severity: UCEIS], histological [Nancy Index] and clinical [Simple Clinical Colitis Activity Index: SCCAI] severity indices, along with routine blood measurements. A blinded principal component analysis spontaneously separated metabolite profiles of patients with low [≤3] and high [>3] UCEIS. Orthogonal partial least squares discrimination analysis identified low and high UCEIS metabolite profiles with an accuracy of 77 ± 5%. Plasma metabolites driving discrimination included decreases in lipoproteins and increases in isoleucine, valine, glucose and myo-inositol in high compared to low UCEIS. This same metabolite profile distinguished between low [Nancy 0-1] and high histological act...Continue Reading

References

Oct 15, 1998·Gut·R S WalmsleyR N Allan
Dec 14, 2001·European Journal of Gastroenterology & Hepatology·I E KoutroubakisE A Kouroumalis
Jun 24, 2003·The American Journal of Gastroenterology·Sunanda V KaneStephen B Hanauer
Dec 6, 2003·Journal of Pharmaceutical and Biomedical Analysis·E M LenzA F P Nash
Oct 9, 2004·Inflammatory Bowel Diseases·Séverine VermeirePaul Rutgeerts
Feb 3, 2007·Journal of Proteome Research·Julian R MarchesiYulan Wang
Jul 5, 2008·Magnetic Resonance Imaging·Krithika BalasubramanianNaranamangalam R Jagannathan
Nov 28, 2008·Alimentary Pharmacology & Therapeutics·G RomanatoE Manzato
Mar 18, 2009·Inflammatory Bowel Diseases·Javier P GisbertJosé Maté
Jun 6, 2009·The American Journal of Gastroenterology·Horace R T WilliamsTimothy R Orchard
Jun 30, 2009·Wiener klinische Wochenschrift·Vladimír HrabovskýAlice Mendlová
Dec 3, 2010·Journal of Clinical Lipidology·Raja Shekhar R Sappati BiyyaniKevin D Mullen
May 26, 2012·Journal of Crohn's & Colitis·Natasha S StephensCarolyn M Slupsky
Mar 21, 2013·Biochemical and Biophysical Research Communications·Ying ZhangChangqing Zheng
Jul 31, 2013·Gastroenterology·Simon P L TravisWilliam J Sandborn
Oct 15, 2013·Journal of Crohn's & Colitis·A J WalshS P L Travis
Jan 15, 2014·World Journal of Gastroenterology : WJG·Tomasz DawiskibaPiotr Młynarz
May 6, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mark T OstermanUNKNOWN DEAR Investigators
Jan 20, 2015·Metabolomics : Official Journal of the Metabolomic Society·Jacob Tveiten BjerrumOle Haagen Nielsen
Aug 26, 2015·The American Journal of Gastroenterology·L Peyrin-BirouletJ-F Colombel
Oct 16, 2015·Gut·Aude Marchal-BressenotLaurent Peyrin-Biroulet
Oct 31, 2015·Digestive Diseases and Sciences·Efstratios KoutroumpakisDavid G Binion
Sep 10, 2016·BMC Medicine·Arnald AlonsoUNKNOWN IMID Consortium
Jan 24, 2017·Alimentary Pharmacology & Therapeutics·L VuittonP Marteau
Jun 24, 2017·World Journal of Gastroenterology : WJG·Ammar Hassanzadeh KeshteliLevinus A Dieleman
Nov 16, 2017·Nucleic Acids Research·David S WishartAugustin Scalbert

❮ Previous
Next ❯

Citations

Jan 16, 2020·Journal of Medical Internet Research·Sarah M GooddayJohn Geddes
Nov 12, 2020·Journal of Crohn's & Colitis·Kate GallagherHorace R T Williams
Jun 2, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Shiqin JiangJing Jin
Aug 23, 2021·EBioMedicine·Jacob T BjerrumOle H Nielsen

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear magnetic resonance
NMR
PCA
biopsies

Software Mentioned

R scripts
R
ropls
in
R Foundation for Statistical Computing
Topspin
house
DA
OPLS

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.