Plasma orexin A increases at emergence from sevoflurane-fentanyl anesthesia in patients undergoing ophthalmologic surgery

Neuroscience Letters
Tetsuya KushikataKazuyoshi Hirota

Abstract

Central orexinergic and noradrenergic neurons are involved in the control of sleep and wakefulness. In addition, previous reports suggest that both neurons may have an important role to play in general anesthesia. In the present study, we have determined whether general anesthesia would affect plasma orexin A (OXA) and norepinephrine concentrations. Twelve patients scheduled for elective ophthalmic surgery under general anesthesia with sevoflurane, fentanyl and vecuronium were studied. Arterial blood was collected before and 1 and 2h after induction of anesthesia and at emergence to measure plasma OXA, cortisol, norepinephrine and epinephrine concentrations. During anesthesia the inhalational concentration of sevoflurane was changed to maintain the bispectral index between 40 and 50. Plasma OXA, cortisol, norepinephrine and epinephrine did not change during anesthesia but significantly increased after emergence compared to pre-anesthesia (from 14.8+/-1.7 to 21.4+/-1.7 pM, p<0.01, from 26.5+/-5.2 to 52.8+/-6.0 pM, p<0.01, from 263+/-46 to 513+/-89 pM, p<0.01, and from 1239+/-120 to 1631+/-203 pM, p<0.01, respectively). There were significant correlations of plasma OXA with cortisol (r=0.334, p<0.05) and epinephrine (r=0.292, p<0...Continue Reading

References

Feb 14, 2002·Neuroscience Letters·S HiguchiT Sakurai
Feb 15, 2002·Endocrine Reviews·Annette L Kirchgessner
Mar 7, 2002·British Journal of Anaesthesia·K Hirota, T Kushikata
Dec 28, 2002·Diabetes·Raogo OuedraogoAnnette L Kirchgessner
Oct 29, 2003·Neuroscience·T KushikataA Matsuki
Dec 17, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Raphaëlle Winsky-SommererLuis de Lecea
Mar 2, 2006·Pharmacological Reviews·Raffaella SpinazziGastone G Nussdorfer
Jan 24, 2007·Anesthesia and Analgesia·Ying HeKazuyoshi Hirota
Jan 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Max B KelzMasashi Yanagisawa
Mar 15, 2008·Acta Anaesthesiologica Scandinavica·E MaranaR Proietti

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Citations

Oct 11, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Raouf AminThomas Inge
Mar 19, 2019·Anesthesia and Analgesia·Max B KelzKen Solt
Jul 17, 2012·Anesthesia and Analgesia·Li-Na ZhangHai-Long Dong
Oct 23, 2018·World Journal of Methodology·Marco CascellaMaria Rosaria Muzio
Apr 16, 2021·Anesthesia and Analgesia·Olivia A MoodyKen Solt

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