Plasma osmolality dipsogenic thresholds and c-fos expression in the near-term ovine fetus

Pediatric Research
Z XuM G Ross

Abstract

In ovine and human pregnancy, fetal swallowing contributes importantly to amniotic fluid homeostasis. Fetal dipsogenic responsiveness to short-term plasma hyperosmolality develops in late gestation, although fetal swallowing is not stimulated in response to long-term plasma osmolality increases (2 to 3%), which typically stimulate adult drinking behavior. To explore the near-term fetal plasma osmolality threshold for swallowing stimulation, we examined the effects of i.v. hypertonic saline-induced subacute increases in plasma hypertonicity on fetal swallowing behavior. Central sites of activation were examined by c-fos expression in putative dipsogenic nuclei. The results demonstrate that subacute 2 to 3% plasma osmolality increases do not stimulate near-term ovine fetal swallowing. However, fetal swallowing activity significantly increased (3 times) after plasma osmolality increased >6% above basal values. Consistent with a specific dipsogenic response, i.v. hypertonic saline induced c-fos expression in the anterior third ventricle region, a putative dipsogenic center, as well as in the fetal hindbrain. The stimulation of fetal swallowing under conditions of higher osmotic stimulation and the correlation with forebrain c-fos e...Continue Reading

References

Feb 3, 1978·Brain Research·M J McKinleyR S Weisinger
Jan 1, 1992·Hormone Research·G LengS M Luckman
Dec 1, 1989·American Journal of Obstetrics and Gynecology·M G RossJ Humme
Jul 1, 1984·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·R HardingP Johnson
Nov 1, 1982·Physiology & Behavior·G L Edwards, R C Ritter
Jun 1, 1995·Journal of Applied Physiology·M G RossM G Ervin
Jul 1, 1997·Clinical and Experimental Hypertension : CHE·J B MinsonJ P Chalmers
Feb 7, 1998·Endocrine Research·M S GordonM B Gordon
Jul 23, 1998·Physiological Reviews·J T Fitzsimons
Mar 10, 1999·The American Journal of Physiology·E FargeA Dautry-Varsat

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Citations

Jun 24, 2003·Physiology & Behavior·Michael G RossMarie H Beall
Nov 26, 2009·The American Journal of Chinese Medicine·Caiping MaoZhice Xu
Aug 19, 2011·Drug and Chemical Toxicology·Caiping MaoZhice Xu
Oct 2, 2009·Drug and Chemical Toxicology·Yifan ZhangZhice Xu
May 23, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Liyan ZhuZhice Xu
Jan 27, 2007·Placenta·M H BeallM G Ross
Jun 19, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J GuanZ Xu
Mar 31, 2004·Journal of the Society for Gynecologic Investigation·M A El-HaddadM G Ross
Jul 2, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS· Jianli Zheng Caiping Mao
Dec 14, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael G Ross, Mina Desai
Jan 25, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Mina DesaiMichael G Ross
Aug 23, 2003·American Journal of Physiology. Endocrinology and Metabolism·Lijun ShiZhice Xu
Jan 14, 2003·Experimental Biology and Medicine·Shengbiao WangMichael G Ross
Jan 3, 2018·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Micaela E ZywickiPamela J Kling
Nov 14, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lijun ShiZhice Xu
Nov 26, 2015·Journal of the American Animal Hospital Association·Christiane WeingartBarbara Kohn

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