Plasma osteoprotegerin levels predict cardiovascular and all-cause mortality and deterioration of kidney function in type 1 diabetic patients with nephropathy.

Diabetologia
A JorsalLars M Rasmussen

Abstract

The bone-related peptide osteoprotegerin is produced by vascular cells and is involved in the process of vascular calcification. The aim of this study was to investigate the predictive value of plasma levels of osteoprotegerin in relation to mortality, cardiovascular events and deterioration in kidney function in patients with type 1 diabetes. This prospective observational follow-up study included 397 type 1 diabetic patients with overt diabetic nephropathy (243 men; age [mean+/-SD] 42.1 +/- 10.6 years, duration of diabetes 28.3 +/- 9.9 years, GFR 67 +/- 28 ml min(-1) 1.73 m(2)) and a group of 176 patients with longstanding type 1 diabetes and persistent normoalbuminuria (105 men; age 42.6 +/- 9.7 years, duration of diabetes 27.6 +/- 8.3 years). The median (range) follow-up period was 11.3 (0.0-12.9) years. Among patients with diabetic nephropathy, individuals with high osteoprotegerin levels (fourth quartile) had significantly higher all-cause mortality than patients with low levels (first quartile) (covariate-adjusted hazard ratio [HR] 3.00 [1.24-7.27]). High osteoprotegerin levels also predicted cardiovascular mortality (covariate-adjusted HR 4.88 [1.57-15.14]). Furthermore, patients with high osteoprotegerin levels had sig...Continue Reading

References

Jan 1, 1976·Scandinavian Journal of Clinical and Laboratory Investigation·J Bröchner-Mortensen, P Rödbro
Oct 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·B Feldt-RasmussenM Deckert
May 8, 1997·Biochemical and Biophysical Research Communications·E TsudaK Higashio
May 8, 1998·Biochemical and Biophysical Research Communications·A TomoyasuK Higashio
Jun 11, 1998·The Journal of Biological Chemistry·J G EmeryP R Young
May 16, 2000·The Journal of Biological Chemistry·U M MalyankarC M Giachelli
Feb 7, 2001·The Journal of Clinical Endocrinology and Metabolism·W S BrownerS R Cummings
Feb 20, 2002·Trends in Cardiovascular Medicine·Marta Scatena, Cecilia Giachelli
Apr 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Michael SchoppetLorenz C Hofbauer
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Kerry L TysonCatherine M Shanahan
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Michael SchoppetLorenz C Hofbauer
Sep 19, 2003·Lancet·Marc A PfefferUNKNOWN CHARM Investigators and Committees
Nov 16, 2004·Journal of the American College of Cardiology·Thor UelandPål Aukrust
May 27, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·L M Rasmussen, T Ledet
Dec 3, 2005·European Journal of Endocrinology·Fiorella GalluzziFrancesco Chiarelli
May 10, 2006·Journal of the American College of Cardiology·Dhakshinamurthy Vijay AnandRoger Corder
May 12, 2006·Journal of the American Society of Nephrology : JASN·Jøran HjelmesaethAnders Hartmann
Aug 22, 2006·Current Molecular Medicine·S DellegrottaglieS Rajagopalan
Oct 7, 2006·Diabetes Research and Clinical Practice·Guang-da XiangLin-shuang Zhao
Oct 21, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Paula ClancyJonathan Golledge
Oct 24, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Ping OlesenLars Melholt Rasmussen
Feb 13, 2007·The American Journal of Cardiology·Moeen AbedinJames A de Lemos
Jul 14, 2007·Medicinal Chemistry·Mauro VaccarezzaMarina Zweyer
Aug 21, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lise TarnowUNKNOWN EURAGEDIC Consortium
Feb 7, 2008·Diabetes Care·Anne Sofie AstrupHans-Henrik Parving
Feb 22, 2008·Journal of the American Society of Nephrology : JASN·Corina LorzAlberto Ortiz

❮ Previous
Next ❯

Citations

Apr 29, 2010·Current Diabetes Reports·Trevor J Orchard, Tina Costacou
Dec 25, 2010·Molecular & Cellular Proteomics : MCP·Atul J ButteMinnie M Sarwal
Dec 17, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·My SvenssonHallvard Holdaas
Aug 2, 2011·Cardiovascular Diabetology·Henrik ReinhardPeter K Jacobsen
Jun 24, 2010·Journal of Psychiatry & Neuroscience : JPN·Sigrun HopeOle A Andreassen
Mar 1, 2011·Journal of the American Society of Nephrology : JASN·Elizabeth T RosolowskyAndrzej S Krolewski
Jun 27, 2013·Diabetes Care·Daniel GordinUNKNOWN FinnDiane Study Group
Jan 26, 2010·Nature Reviews. Endocrinology·Allan Flyvbjerg
Jul 16, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Mette BjerreUNKNOWN Claricor Trial Group
Apr 18, 2012·Scandinavian Cardiovascular Journal : SCJ·Susanne Elisabeth HosbondHans Mickley
Mar 9, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Jakob GrauslundAnne K Sjølie
Apr 25, 2014·Scandinavian Cardiovascular Journal : SCJ·Mette BjerreHans Erik Bøtker
Nov 1, 2012·Annals of Medicine·Martina MontagnanaGian Cesare Guidi
Mar 10, 2009·Diabetes/metabolism Research and Reviews
Nov 5, 2011·European Journal of Clinical Investigation·Ana M Blázquez-MedelaCarlos Martínez-Salgado
Mar 28, 2016·Calcified Tissue International·Mahmut Ilker YilmazMehmet Kanbay
Mar 31, 2016·Pediatric Diabetes·Dionisios ChrysisBessie E Spiliotis
Jun 17, 2015·International Journal of Endocrinology·C Pérez de CirizaN Varo
Mar 7, 2015·Journal of Diabetes and Its Complications·Mona Hussein ElsamahyMarwa Magdy Nawar
May 21, 2016·BioMed Research International·Stella BernardiBruno Fabris
Jun 18, 2011·Atherosclerosis·Barbara ToffoliMerlin C Thomas
Jul 30, 2016·Journal of Diabetes and Its Complications·Emilie H ZobelP Rossing
Nov 17, 2015·Therapeutic Advances in Chronic Disease·Siang Ing LeeParth Narendran
Nov 20, 2013·Current Opinion in Nephrology and Hypertension·Riccardo Candido
Oct 12, 2010·Diabetes Care·Henrik ReinhardPeter Rossing
Jun 18, 2021·International Journal of General Medicine·Joanna KamińskaBartosz Foroncewicz

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