Plasma oxytocin changes and anti-obsessive response during serotonin reuptake inhibitor treatment: a placebo controlled study

BMC Psychiatry
Mats B HumbleSusanne Bejerot

Abstract

The drug treatments of choice for obsessive-compulsive disorder (OCD) are serotonin reuptake inhibitors (SRIs). However, a correlation between the neuropeptide oxytocin in cerebrospinal fluid and the severity of OCD has previously been shown, and oxytocin and serotonin are interconnected within the brain. Few studies have investigated whether SRIs have any effect on oxytocin; thus, our aim was to explore the possibility that oxytocinergic mechanisms contribute to the anti-obsessive effect of SRIs. In a randomized, double-blind trial, comparing SRIs (clomipramine and paroxetine) with placebo in 36 adults with OCD (characterized for subtypes), plasma oxytocin was measured with radioimmunoassay after plasma extraction, at baseline, after 1 week, and after 4 weeks of treatment, and related to baseline severity and clinical response after 12 weeks, as measured by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Baseline oxytocin levels correlated positively with baseline Y-BOCS ratings, but only among the future SRI responders. Patients with early onset of OCD had higher baseline oxytocin. During treatment, plasma oxytocin did not differ between SRI and placebo treatment. In SRI responders, plasma oxytocin first decreased and the...Continue Reading

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Citations

Nov 16, 2014·Social Cognitive and Affective Neuroscience·Katrin PreckelRené Hurlemann
Apr 26, 2015·Psychoneuroendocrinology·Marie BendixJussi Jokinen
Jan 30, 2015·Frontiers in Psychology·Kerstin Uvnäs-MobergMaria Petersson
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Dec 22, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Megan GalballyAndrew Lewis
Sep 29, 2018·ACS Sensors·Andrew J Steckl, Prajokta Ray

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Methods Mentioned

BETA
genotyping

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