Plasma phosphatidylcholine alterations in cystic fibrosis patients: impaired metabolism and correlation with lung function and inflammation

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Judith GrotheWolfgang Bernhard

Abstract

Liver impairment, ranging from steatosis to cirrhosis, is frequent in cystic fibrosis (CF) patients and is becoming increasingly significant due to their improved life expectancy. One aspect of hepatic alterations is caused by increased fecal loss of the essential nutrient choline, following enterohepatic bile phosphatidylcholine (PC) cycle impairment. Hepatic PC synthesis, both de novo and via phosphatidylethanolamine-N-methyl-transferase (PEMT), is essential for very low-density lipoprotein (VLDL) secretion. VLDL-PC in particular contributes to the organism's supply with polyunsaturated fatty acids (LC-PUFA), namely arachidonic (C20:4) and docosahexaenoic acid (C22:6). Consequently, choline deprivation and altered hepatic PC metabolism may affect plasma PC homeostasis and extrahepatic organ function. To investigate relationships between altered plasma choline and PC homeostasis and markers of lung function and inflammation in CF. To assess alterations in hepatic choline and PC metabolism of CF patients. Quantification of plasma/serum choline and PC species in adult CF patients compared to controls. Correlation of PC with forced expiratory vital capacity (FEV1) and interleukin 6 (IL-6) concentrations. Analysis of choline and P...Continue Reading

Citations

Mar 30, 2016·Journal of Lipid Research·Puneet PuriArun J Sanyal
Jul 22, 2016·International Journal of Molecular Sciences·Yong TanAiping Lu
May 3, 2018·Journal of Lipid Research·Ahilanandan DushianthanAnthony D Postle
Dec 19, 2015·Expert Review of Clinical Pharmacology·Yuji MiyamotoHideo Baba
Mar 24, 2017·Journal of Pediatric Gastroenterology and Nutrition·Sara MoukarzelSheila M Innis
Oct 16, 2015·Journal of Pediatric Gastroenterology and Nutrition·Joan I SchallVirginia A Stallings
Mar 6, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Wolfgang BernhardChristian F Poets
Mar 13, 2019·European Journal of Nutrition·Wolfgang BernhardAxel R Franz
Mar 21, 2019·Nutrients·Wolfgang BernhardJoachim Riethmüller
Oct 10, 2018·European Journal of Nutrition·Wolfgang BernhardAxel R Franz
Oct 11, 2020·EBioMedicine·Clarisse Vandebrouck, Thierry Ferreira
Jan 25, 2021·Analytica Chimica Acta·Sin Man LamGuanghou Shui
Jul 22, 2021·European Journal of Nutrition·Katrin A BöckmannWolfgang Bernhard

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