Plasma phospholipid transfer activity is essential for increased atherogenesis in PLTP transgenic mice: a mutation-inactivation study.

Journal of Lipid Research
Hannelore SamynRini de Crom

Abstract

Plasma phospholipid transfer protein (PLTP) interacts with HDL particles and facilitates the transfer of phospholipids from triglyceride (TG)-rich lipoproteins to HDL. Overexpressing human PLTP in mice increases the susceptibility to atherosclerosis. In human plasma, high-active and low-active forms of PLTP exist. To elucidate the contribution of phospholipid transfer activity to changes in lipoprotein metabolism and atherogenesis, we developed mice expressing mutant PLTP, still able to associate with HDL but lacking phospholipid transfer activity. In mice heterozygous for the LDL receptor, effects of the mutant and normal human PLTP transgene (mutPLTP tg and PLTP tg, respectively) were compared. In PLTP tg mice, plasma PLTP activity was increased 2.9-fold, resulting in markedly reduced HDL lipid levels. In contrast, in mutPLTP tg mice, lipid levels were not different from controls. Furthermore, hepatic VLDL-TG secretion was stimulated in PLTP tg mice, but not in mutPLTP tg mice. When mice were fed a cholesterol-enriched diet, atherosclerotic lesion size in PLTP tg mice was increased more than 2-fold compared with control mice, whereas in mutPLTP tg mice, there was no change. Our findings demonstrate that PLTP transfer activity...Continue Reading

References

Dec 1, 1987·Atherosclerosis·B PaigenR A Williams
May 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·K J Williams, I Tabas
May 24, 1996·The Journal of Biological Chemistry·E HailmanS D Wright
Apr 15, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·R van HaperenR de Crom
Dec 22, 2000·Biochemistry·J HuuskonenM Jauhiainen
Apr 6, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S JaariC Ehnholm
Dec 4, 2001·Biochimica Et Biophysica Acta·C J Fielding, P E Fielding
Oct 10, 2002·The Journal of Biological Chemistry·Rien van HaperenRini de Crom
Aug 30, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Axel SchlittXian-Cheng Jiang
Dec 26, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi YatsuyaHideaki Toyoshima
Jul 11, 2006·FEBS Letters·Karel W A Wirtz
Oct 14, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Ruijie LiuXian-Cheng Jiang
Jun 8, 2007·Atherosclerosis·Wilfried SchgoerBernhard Foeger
Sep 1, 2007·Journal of Lipid Research·Matthijs MoerlandRini de Crom

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Citations

Nov 26, 2009·The Journal of Pharmacology and Experimental Therapeutics·Yi LuoXian-Cheng Jiang
Sep 2, 2010·The Journal of Pharmacology and Experimental Therapeutics·Yi LuoXian-Cheng Jiang
Feb 22, 2013·The Journal of Clinical Investigation·Roland KlingenbergGöran K Hansson
Jun 11, 2010·Lipids in Health and Disease·Marius R RobciucMatti Jauhiainen
Sep 8, 2009·Atherosclerosis·Eder C R Quintão, Patrícia M Cazita
Jul 9, 2011·Biochimica Et Biophysica Acta·John J AlbersMarian C Cheung
May 9, 2009·Biochimica Et Biophysica Acta·Hannelore SamynRini de Crom
Jul 15, 2015·Atherosclerosis·Stephen D Lee, Peter Tontonoz

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