Plasma phospholipid transfer protein (PLTP) modulates adaptive immune functions through alternation of T helper cell polarization

Cellular & Molecular Immunology
Catherine DesrumauxLaurent Lagrost

Abstract

Plasma phospholipid transfer protein (PLTP) is a key determinant of lipoprotein metabolism, and both animal and human studies converge to indicate that PLTP promotes atherogenesis and its thromboembolic complications. Moreover, it has recently been reported that PLTP modulates inflammation and immune responses. Although earlier studies from our group demonstrated that PLTP can modify macrophage activation, the implication of PLTP in the modulation of T-cell-mediated immune responses has never been investigated and was therefore addressed in the present study. Approach and results: In the present study, we demonstrated that PLTP deficiency in mice has a profound effect on CD4+ Th0 cell polarization, with a shift towards the anti-inflammatory Th2 phenotype under both normal and pathological conditions. In a model of contact hypersensitivity, a significantly impaired response to skin sensitization with the hapten-2,4-dinitrofluorobenzene (DNFB) was observed in PLTP-deficient mice compared to wild-type (WT) mice. Interestingly, PLTP deficiency in mice exerted no effect on the counts of total white blood cells, lymphocytes, granulocytes, or monocytes in the peripheral blood. Moreover, PLTP deficiency did not modify the amounts of CD...Continue Reading

References

May 4, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C DesrumauxL Lagrost
Nov 18, 2000·Heart·Y SetaM Kurabayashi
Aug 8, 2001·The Journal of Experimental Medicine·S L Swain
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·O AdolfssonS N Meydani
Jun 28, 2003·Cardiovascular Research·Rima ElhageGöran K Hansson
Sep 2, 2003·Cytokine & Growth Factor Reviews·Wendy T WatfordJohn J O'Shea
Apr 27, 2004·Trends in Immunology·Colin D Bingle, C Jeremy Craven
Dec 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Catherine DesrumauxLaurent Lagrost
May 3, 2005·Biochimica Et Biophysica Acta·Axel SchlittXian-Cheng Jiang
May 11, 2005·Immunological Reviews·Simin Nikbin MeydaniDayong Wu
Feb 10, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Véronique DrouineaudValérie Deckert
Jul 11, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Alexis KleinLaurent Lagrost
May 6, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·T TzotzasL Lagrost
Jan 8, 2010·Arthritis Research & Therapy·Francesco Annunziato, Sergio Romagnani
Mar 9, 2010·Current Opinion in Pharmacology·Soraya TalebZiad Mallat
Sep 25, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Catherine DesrumauxLaurent Lagrost
Jan 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·David MassonLaurent Lagrost
Mar 23, 2011·Vitamins and Hormones·Didem Pekmezci
Jul 9, 2011·Biochimica Et Biophysica Acta·John J AlbersMarian C Cheung
Oct 8, 2011·International Journal of Immunopathology and Pharmacology·A SagginiY B Shaik-Dasthagirisaheb
Aug 18, 2012·Nutrition & Metabolism·Xian-Cheng JiangMahmood M Hussain
Nov 28, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Emese IzsepiJanos Matko
Jul 9, 2013·The American Journal of Pathology·Valérie DeckertLaurent Lagrost
Jul 13, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Amirfarbod YazdanyarXian-Cheng Jiang
Aug 14, 2013·Annual Review of Pathology·Joseph L Witztum, Andrew H Lichtman
Oct 25, 2013·International Immunology·Kevin TseKlaus Ley
Apr 29, 2014·Human Immunology·Amy H Newton, Stephen H Benedict

❮ Previous
Next ❯

Citations

May 8, 2018·Cellular & Molecular Immunology·Catherine Desrumaux, Laurent Lagrost
Aug 3, 2017·Journal of Lipid Research·Véronique PerrierCatherine Desrumaux
Jan 15, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jingbo PangTimothy J Koh
Jan 27, 2021·Current Atherosclerosis Reports·Xian-Cheng Jiang, Yang Yu
Mar 30, 2021·ACS Omega·Xiaoling LiuBende Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here