Plasma polyunsaturated fatty acids and regional cerebral glucose metabolism in major depression.

Prostaglandins, Leukotrienes, and Essential Fatty Acids
M Elizabeth SubletteJ John Mann

Abstract

Deficiencies in polyunsaturated essential fatty acids (PUFA) are implicated in mood disorders, although mechanisms of action and regional specificity in the brain are unknown. We hypothesized that plasma phospholipid PUFA levels are correlated with regionally specific relative cerebral metabolic rates of glucose (rCMRglu). Medication-free depressed subjects (N=29) were studied using [(18)F]-fluoro-2-deoxyglucose positron emission tomography. Docosahexaenoic acid (22:6n-3), arachidonic acid (20:4n-6), and eicosapentaenoic acid (20:5n-3) were assessed as a percentage of total phospholipid PUFA (DHA%, AA%, and EPA%, respectively). DHA% and AA% correlated positively with rCMRglu in temporoparietal cortex. In addition, DHA% correlated negatively with rCMRglu in prefrontal cortex and anterior cingulate. No correlations were seen with EPA%. Thus, under conditions of low plasma DHA, rCMRglu was higher in temporoparietal cortex and lower in anterior cingulate/prefrontal cortex. Opposing effects of DHA on these regions is a hypothesis that could be addressed in future prospective studies with n-3 supplementation. This pilot study is the first to demonstrate fatty acid and regionally specific correlations in the brain between plasma PUFA ...Continue Reading

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Citations

Feb 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J John Mann
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May 12, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Stephen C CunnanePascale Barberger-Gateau
Apr 24, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Robert K McNamara
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Mar 19, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marta Casquero-VeigaMaría Luisa Soto-Montenegro

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