Abstract
Plasma potassium is a moderately heritable phenotype, but no robust associations between common single nucleotide polymorphisms (SNPs) and plasma potassium have previously been described. Genetic influences on renal potassium handling could be important in the etiology of hypertension. We have tested whether common genetic variation in the gene encoding the beta-subunit of the epithelial sodium channel (SCNN1B) affects plasma potassium and blood pressure level in a study of 1,425 members of 248 families ascertained on a proband with hypertension. We characterized family members for blood pressure using ambulatory monitoring, measured plasma potassium in venous blood samples, and genotyped four SNPs that spanned the SCNN1B gene. We found highly significant association between genotype at the SCNN1B rs889299 SNP situated in intron 4 of the gene and plasma potassium. Homozygotes for the rarer T allele had on average a 0.15 mM lower plasma potassium than homozygotes for the common C allele, with an intermediate value for heterozygotes (trend, P = 0.0003). Genotype at rs889299 accounted for approximately 1% of the total variability in plasma potassium, or around 3% of the total heritable fraction. There was no association between ge...Continue Reading
References
Sep 1, 1987·British Heart Journal·J G ClelandB W East
Jan 1, 1985·Genetic Epidemiology·J B Whitfield, N G Martin
Sep 7, 1974·British Medical Journal·V M HawthorneD G Beevers
May 1, 1984·Annals of Clinical Biochemistry·J B Whitfield, N G Martin
Sep 1, 1995·Nature Genetics·J H HanssonR P Lifton
Nov 4, 1994·Cell·R A ShimketsJ W Findling
Mar 1, 1996·Nature Genetics·S S ChangR P Lifton
Apr 1, 1997·American Journal of Epidemiology·S G WannametheeP H Whincup
Apr 17, 1997·The New England Journal of Medicine·L J AppelN Karanja
May 21, 1998·Lancet·E H BakerG A MacGregor
Jul 23, 1998·Hypertension·A PersuX Jeunemaitre
Oct 16, 1999·Hypertension·W T AmbrosiusJ H Pratt
Mar 4, 2000·American Journal of Hypertension·K IshikawaT Ogihara
Dec 4, 2001·Nature Genetics·Gonçalo R AbecasisLon R Cardon
Aug 24, 2002·Clinical Science·David J HunterTim D Spector
Nov 4, 2004·The Journal of Clinical Endocrinology and Metabolism·Bernard KeavneyJohn Connell
Jun 7, 2005·Journal of Medical Genetics·N GaukrodgerB Keavney
Jun 11, 2005·Bioinformatics·Janis E Wigginton, Gonçalo R Abecasis
Jul 9, 2005·Life Sciences·Dolores Nieto MartínJoaquín Carneado de la Fuente
Jul 28, 2005·Diabetes·Michelle BakerBernard Keavney
Sep 30, 2005·Journal of the American Society of Nephrology : JASN·J Howard Pratt
Sep 21, 2006·The Journal of Clinical Endocrinology and Metabolism·Helen ImrieJohn M C Connell
Dec 2, 2006·BMC Medical Genetics·Darroch H HallBernard Keavney
Sep 21, 2007·Nature·Jayasankar JastiEric Gouaux
Citations
Oct 30, 2016·International Journal of Epidemiology·Ivette Ag DeckersLeo J Schouten
Nov 30, 2018·Endocrine Connections·Peng FanXian-Liang Zhou
Mar 28, 2018·Clinical and Experimental Hypertension : CHE·Simiat O EliasSmith I Jaja
Jun 2, 2021·Scientific Reports·Yijun LiKe Wang
Apr 25, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity