Plasma potassium level is associated with common genetic variation in the beta-subunit of the epithelial sodium channel

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Nicole GaukrodgerBernard D Keavney

Abstract

Plasma potassium is a moderately heritable phenotype, but no robust associations between common single nucleotide polymorphisms (SNPs) and plasma potassium have previously been described. Genetic influences on renal potassium handling could be important in the etiology of hypertension. We have tested whether common genetic variation in the gene encoding the beta-subunit of the epithelial sodium channel (SCNN1B) affects plasma potassium and blood pressure level in a study of 1,425 members of 248 families ascertained on a proband with hypertension. We characterized family members for blood pressure using ambulatory monitoring, measured plasma potassium in venous blood samples, and genotyped four SNPs that spanned the SCNN1B gene. We found highly significant association between genotype at the SCNN1B rs889299 SNP situated in intron 4 of the gene and plasma potassium. Homozygotes for the rarer T allele had on average a 0.15 mM lower plasma potassium than homozygotes for the common C allele, with an intermediate value for heterozygotes (trend, P = 0.0003). Genotype at rs889299 accounted for approximately 1% of the total variability in plasma potassium, or around 3% of the total heritable fraction. There was no association between ge...Continue Reading

References

Sep 7, 1974·British Medical Journal·V M HawthorneD G Beevers
May 1, 1984·Annals of Clinical Biochemistry·J B Whitfield, N G Martin
Apr 1, 1997·American Journal of Epidemiology·S G WannametheeP H Whincup
Dec 4, 2001·Nature Genetics·Gonçalo R AbecasisLon R Cardon
Aug 24, 2002·Clinical Science·David J HunterTim D Spector
Jun 11, 2005·Bioinformatics·Janis E Wigginton, Gonçalo R Abecasis
Sep 30, 2005·Journal of the American Society of Nephrology : JASN·J Howard Pratt
Sep 21, 2006·The Journal of Clinical Endocrinology and Metabolism·Helen ImrieJohn M C Connell
Sep 21, 2007·Nature·Jayasankar JastiEric Gouaux

❮ Previous
Next ❯

Citations

Mar 28, 2018·Clinical and Experimental Hypertension : CHE·Simiat O EliasSmith I Jaja
Apr 25, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

© 2021 Meta ULC. All rights reserved