Abstract
To determine the inter-relationships between cytokine levels and physiological scores in predicting outcome in unselected, critically ill patients. To this end, 127 patients (96 men), having a mean+/-SD age of 45+/-20 years, with a wide range in admission diagnoses (medical, surgical, and multiple trauma patients) were prospectively investigated. Severity of critical illness and organ dysfunction were graded by acute physiology and chronic health evaluation (APACHE II) and sequential organ failure assessment (SOFA) scores, respectively. Blood samples were drawn on admission in the ICU to determine pro- and anti-inflammatory cytokines, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-8, and IL-10. The main outcome measure was 28-day mortality. Overall, 88 patients survived and 39 patients died. Univariate logistic regression analysis showed that SOFA, APACHE II, IL-8, IL-6, and IL-10 on admission in the ICU were related to mortality. Multiple logistic regression analysis in the entire cohort of critically ill patients revealed that SOFA (OR=1.341, p<0.001) and IL-6 (OR=1.075, p=0.01) constituted independent outcome predictors. receiver operator characteristics curve analysis showed that SOFA, APACHE II, and IL...Continue Reading
References
Apr 1, 1992·Annals of Surgery·P DamasM Lamy
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Dec 1, 1993·Annals of Surgery·R M RoumenR J Goris
Oct 15, 1993·Annals of Internal Medicine·L C CaseyR C Bone
Feb 1, 1993·Chest·M R PinskyE Dupont
Dec 1, 1996·Burns : Journal of the International Society for Burn Injuries·Y YamadaK Inada
May 1, 1997·The Journal of Trauma·R NeidhardtW Ertel
Nov 21, 1997·Critical Care Medicine·C MartinJ L Mege
Dec 24, 1997·Chest·C A Dinarello
Sep 12, 1998·Lancet·J T van DisselM Frölich
May 8, 1999·Pancreas·T BerneyP Morel
Aug 14, 1999·Critical Care Medicine·T TaniguchiA Kurokawa
Dec 23, 1999·The Journal of Infectious Diseases·C A GogosA Skoutelis
May 12, 2000·Critical Care Medicine·A OberholzerL L Moldawer
Sep 21, 2001·Cytokine·M Rodríguez-GasparJ L Gómez-Sirvent
Sep 5, 2002·Intensive Care Medicine·Ville PettiläMatti Valtonen
Mar 29, 2003·Intensive Care Medicine·Mitchell M LevyUNKNOWN International Sepsis Definitions Conference
Jun 19, 2003·Shock·Marja HynninenMatti Valtonen
Apr 3, 2004·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·C WunderN Roewer
May 15, 2004·Surgical Infections·Daniel A BonvillePhilip S Barie
Jan 18, 2005·Cytokine·Shigeto OdaMasataka Nakamua
Aug 10, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y HeperS Helvaci
Mar 21, 2007·Cytokine·Olga LivaditiEmmanuel E Douzinas
Apr 13, 2007·Cytokine·Ioanna DimopoulouEvangelos J Giamarellos-Bourboulis
Apr 24, 2007·Critical Care : the Official Journal of the Critical Care Forum·Fernando A BozzaPatrícia T Bozza
Citations
Oct 8, 2011·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Menachem OberbaumMoshe Hersch
May 16, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Joel M BaumgartnerMartin D McCarter
Nov 15, 2008·Shock·Andres TorresYoram Vodovotz
Jan 29, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Kaveh EslamiMojtaba Mojtahedzadeh
Aug 8, 2009·European Journal of Medical Research·V BognerP Biberthaler
Jun 30, 2011·Critical Care : the Official Journal of the Critical Care Forum·Mary WhiteThomas Ryan
Jul 5, 2008·Critical Care : the Official Journal of the Critical Care Forum·Pavlos M Myrianthefs, George J Baltopoulos
Jun 13, 2009·Critical Care : the Official Journal of the Critical Care Forum·Chlodwig KirchhoffSiegfried Zedler
Dec 5, 2012·Neurosurgery·Carl MuroiEmanuela Keller
Dec 23, 2009·PloS One·Rajaie NamasYoram Vodovotz
Jan 10, 2014·American Journal of Respiratory Cell and Molecular Biology·Oliver FriedrichMirko Völkers
Jan 7, 2009·Mediators of Inflammation·Alasdair George SutherlandJames D Hutchison
Jan 17, 2009·World Journal of Surgery·Adrian BilleterMarius Keel
Feb 23, 2010·Chest·Wilhelm GranderHerbert Tilg
Sep 18, 2012·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Hadi HamishehkarMojtaba Mojtahedzadeh
Mar 31, 2012·Intensive & Critical Care Nursing : the Official Journal of the British Association of Critical Care Nurses·Chris WinkelmanAlan D Levine
Oct 25, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Carl MuroiE Keller
Sep 21, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Francisco Carlos BonofiglioEduardo de Santibañes
Feb 26, 2011·Injury·Tiansheng SunJianzheng Zhang
Oct 31, 2008·Scandinavian Journal of Immunology·S K TschoekeA Oberholzer
Apr 4, 2016·Journal of Clinical Monitoring and Computing·T TambuyzerG Meyfroidt
Jan 6, 2015·Paediatric Anaesthesia·Mary C TherouxThomas H Shaffer
Jun 16, 2012·Journal of Critical Care·Dimitra A VassiliadiIoanna Dimopoulou
Aug 22, 2014·Cell Biochemistry and Biophysics·Xiao-Di Xu, Feng Shao
Oct 12, 2018·Metabolites·Ioannis IliasIoanna Dimopoulou
May 31, 2014·Biological Research for Nursing·Chris WinkelmanNahida Gordon
Dec 17, 2016·Shock·Rémi CoudroyUNKNOWN ABDOMIX group
Jan 15, 2016·Khirurgiia·B S SukhovatykhYu Yu Blinkov
Aug 25, 2019·Medicina·Mohammed I M GubariMohammad Javad Hosseinzadeh-Attar
Jan 1, 2021·The Bone & Joint Journal·Babar KayaniFares S Haddad
Dec 29, 2020·MSystems·Cecilia AmbrosiAnna Teresa Palamara