PMID: 22571894May 11, 2012Paper

Plasma profiles of glucose, insulin and lipids in the male WBN/Kob-Lepr(fa) rat, a new model of type 2 diabetes with obesity

The Journal of Veterinary Medical Science
Noriyuki KajiFumitoshi Asai

Abstract

Plasma profiles of glucose, insulin and lipids were examined in the male WBN/Kob-Lepr(fa) (fa/fa) rat, a new model of type 2 diabetes (T2D), in comparison with age-matched original male WBN/Kob (lean) rats. The fa/fa rats developed hypertriglycemia, obesity and hyperglycemia from 5, 7, and 9 weeks of age, respectively. Plasma insulin levels in fa/fa rats were significantly higher than those in lean rats at 5 weeks of age, but after 11 weeks of age gradually declined to the levels in lean rats. HOMA-IR, a measure of insulin resistance status, showed that fa/fa rats had insulin resistance. The fa/fa rat has the potential to become an important animal model of T2D with obesity.

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Citations

May 1, 2013·The Journal of Veterinary Medical Science·Noriyuki KajiFumitoshi Asai
Apr 23, 2020·Animal Models and Experimental Medicine·Noriyuki KajiFumitoshi Asai
Sep 26, 2014·Nihon eiseigaku zasshi. Japanese journal of hygiene·Yuji TakedaIchiro Wakabayashi
Jul 19, 2019·Nutrients·Takanobu TakataMasayoshi Takeuchi
Nov 20, 2016·Clinical and Experimental Pharmacology & Physiology·Yoshiichi TakagiFumitoshi Asai
Jul 31, 2013·The Journal of Veterinary Medical Science·Akira OkunoFumitoshi Asai

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