Plasma Prolidase Activity and Oxidative Stress in Patients with Parkinson's Disease

Parkinson's Disease
Akhilesh Kumar VermaRagini Srivastava

Abstract

Prolidase deficiency has been related to mental retardation and oxidative stress. The study aimed to observe plasma prolidase activity (PPA), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) in patients with Parkinson's disease (PD). 240 subjects with PD and 150 healthy volunteers were considered as cases and controls, respectively. PPA, TOS, TAS, and OSI were measured spectrophotometrically. PPA and TAS in cases were more significantly decreased than controls (P < 0.01), while TOS and OSI were significantly increased (P < 0.001). In cases, nonsignificant, positive correlation was observed between PPA and TOS and OSI while significant, negative correlation was observed between PPA and TAS (P = 0.047). PPA in cases was nonsignificantly decreased with increased duration of PD (P = 0.747) while TAS was significantly decreased (P < 0.001) and TOS and OSI were significantly increased (P < 0.001). It was observed that higher age groups had decreased PPA, and TAS and increased TOS and OSI compared to lower age groups in cases. In summary, patients with PD have decreased PPA and increased oxidative stress compared to healthy volunteers. PPA was associated with oxidative stress markers in pati...Continue Reading

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Citations

Sep 15, 2015·Biological Trace Element Research·Akhilesh Kumar VermaRagini Srivastava
Apr 17, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Mehmet TetikoğluFatih Özcura
Feb 20, 2018·Oxidative Medicine and Cellular Longevity·Barbara PietruchaBozena Mikoluc
Jun 27, 2020·Asian Journal of Psychiatry·Geethu KrishnaSarada Subramanian
Oct 14, 2021·Molecular Biology Reports·Irmak Ferah OkkayAhmet Hacimuftuoglu

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