Plasma propranolol levels associated with reductions in endogenous and exogenous cardiac beta-stimulation were determined in normal people. The levels associated with a given degree of blockade of exercise-induced tachycardia were about three times greater after intravenous administration than after oral administration. This shows that an active metabolite of propranolol is formed only after the drug is taken by mouth. The greatest reduction in the tachycardia of strenuous exercise was associated with plasma levels of 40 ng./ml. with oral administration and 100 ng./ml. with intravenously administered propranolol.The effect on isoprenaline-induced tachycardia following intravenously administered propranolol showed that the dose ratio for isoprenaline was about 30 with plasma levels of 100 ng./ml. and 10 with levels of 10-20 ng./ml. These plasma levels give 100% and 20-30% blockade of exercise-induced tachycardia. These findings suggest that some of the therapeutic effects of propranolol may be unrelated to beta-adrenergic blockade.
Effects of propranolol on the transmembrane potentials of ventricular muscle and Purkinje fibers of the dog
Control of heart rate by the autonomic nervous system. Studies in man on the interrelation between baroreceptor mechanisms and exercise
A controlled evaluation of propranolol in chronic alcoholic patients presenting the symptomatology of anxiety and tension
Enantioselective assays in comparative bioavailability studies of racemic drug formulations: nice to know or need to know?
Ethnic differences in response to beta-blockade: fact or artefact? A study with bisoprolol and propranolol
Receptor binding of propranolol is the missing link between plasma concentration kinetics and the effect-time course in man
An investigation of the relationship between beta-adrenoceptor blockade and plasma practolol concentration in man
An investigation of "absolute plasma level effect relationships" and "absolute cardioselectivity" with respect to beta-adrenoceptor blockade
Pharmacokinetics and pharmacodynamics of alprenolol in the treatment of hypertension. II. Relationship to its effect on blood pressure and plasma renin activity
Effects of (+)-propranolol on intracellular mechanisms of contraction in striated muscle of the rabbit
Relationship of propranolol pharmacokinetics to antihypertensive effect and beta-adrenergic blockade in the treatment of hypertension
The use of propranolol in rapid sequence anaesthetic induction: optimal time interval for pretreatment
Clinical pharmacology of the new beta-adrenergic blocking drugs. Part 7. New horizons in beta-adrenoceptor blockade therapy: labetalol
A comparison of the actions of ICI66082 and propranolol on cardiac and peripheral beta-adrenoceptors
Epicardial propranolol administration for ventricular arrhythmias in dogs: matrix formulation and characterization
Epinephrine-induced changes in serum potassium and cardiac repolarization and effects of pretreatment with propranolol and diltiazem
Intrinsic sympathomimetic activity and the effects of beta-adrenergic blocking drugs on vulnerability to ventricular fibrillation
Abnormal left ventricular function in hyperthyroidism: evidence for a possible reversible cardiomyopathy
An investigation into the cardiac and pulmonary beta-adrenoceptor blocking activity of ICI 66,082 in man
The effect of acute vs chronic treatment with beta-adrenoceptor blockade on exercise performance, haemodynamic and metabolic parameters in healthy men and women
Assessment of relative actions of beta-adrenergic blocking drugs on heart rate and left ventricular ejection using a non-invasive method in patients with aortic Starr-Edwards prostheses
Investigation of the safe withdrawal period for propranolol in patients scheduled for open heart surgery
Propranolol treatment in children with tetralogy of Fallot alters the response to isoprenaline after surgical repair
Nonadrenergic effects of isoproterenol in dogs with hypoxic pulmonary vasoconstriction. Possible role of prostaglandins
Suppression of ventricular arrhythmias in man by d-propranolol independent of beta-adrenergic receptor blockade
The effect of propranolol on exercise induced tachycardia is determined by plasma concentration and the density of adrenergic receptors on leukocytes
Clinical experience with beta adrenergic blocking agents in myocardial ischaemia: a dilemma and a challenge
Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol and atenolol
Pharmacokinetic studies: their role in determining therapeutic efficacy of agents designed to prevent sudden death
Bioavailability assessment and pharmacologic response: impact of first-pass loss when both drug and metabolites are active
Pharmacokinetics and pharmacodynamics of propranolol in hypertensive patients after sublingual administration: systemic availability
Altered hemoglobin-oxygen affinity with long-term propranolol therapy in patients with coronary artery disease
Effect of propranolol on respiratory function and exercise tolerance in patients with chronic obstructive lung disease
Importance of membrane stabilizing effect in massive overdose of propranolol: plasma level study in a fatal case
Electrophysiologic effects of propranolol on sinus node function in patients with sinus node dysfunction
Effect of propranolol on myocardial oxygen consumption and its hemodynamic correlates during upright exercise
Reversal of abnormal platelet aggregability and change in exercise tolerance in patients with angina pectoris following oral propranolol
Efficacy of propranolol in the control of exercise-induced or augmented ventricular ectopic activity
Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequences
Prediction of tonic parasympathetic cardiac control using respiratory sinus arrhythmia: the need for respiratory control
The effects of propranolol, practolol and metoprolol on exercise-induced tachycardia in relation to plasma levels in man
Cardiovascular responses in hyperthyroidism before and during beta-adrenoceptor blockade: evidence against adrenergic hypersensitivity
Evidence for transient limitations in coronary blood flow during unstable angina pectoris: hemodynamic changes with spontaneous pain at rest versus exercise-induced ischemia following stabilization of angina
Enantioselective analysis of propranolol and 4-hydroxypropranolol by CE with application to biotransformation studies employing endophytic fungi
Effect of meal and propranolol on whole body and splanchnic oxygen consumption in patients with cirrhosis
Optimization of the bacterial cytochrome P450 BM3 system for the production of human drug metabolites
Bronchial and cardiac beta-adrenoceptor blockade--a comparison of atenolol, acebutolol and labetalol
Pindolol--a beta-adrenoceptor blocking drug with partial agonist activity: clinical pharmacological considerations
Effects of indomethacin and (+/-)-propranolol on the cardiovascular and renin responses to vasoactive intestinal polypeptide (VIP) infusion in man
Pharmacodynamic and pharmacokinetic study of propranolol in patients with cirrhosis and portal hypertension
Tonic sympathetic support of metabolic rate is attenuated with age, sedentary lifestyle, and female sex in healthy adults
Concentration-effect relationships with FM 24: a new long acting beta-adrenergic receptor antagonist
Pharmacokinetics and biopharmaceutics of some adrenergic beta-receptor antagonists with special emphasis on alprenolol and metoprolol
Cyclic AMP and plasma renin activity in renal vein blood after amitryptiline, theophylline, furosemide and beta adrenergic blocking substances (author's transl)
Relationship between plasma concentrations and cardiac beta-adrenoceptor blockade--a study with oral and intravenous bopindolol
Transient in oxygen uptake after step-increase of workload under beta-adrenoceptor blockade or vasodilation
The relationship between debrisoquine oxidation phenotype and the pharmacokinetics and pharmacodynamics of propranolol
Pharmacokinetic and pharmacodynamic comparison of two doses of long acting propranolol (80 and 160 mg) in healthy subjects
Proceedings: Comparison of a coronary vasodilator drug (carbochromen) and a cardiac stimulant (oxyfedrin) on blood flow and oxygen extraction in experimental myocardial infarcts
Pharmacokinetics and pharmacodynamics of alprenolol in the treatment of hypertension. I. Relationship between plasma concentration and adrenergic beta-receptor blockade
Ventricular antiarrhythmic effects of beta-adrenergic blocking drugs: a review of mechanism and clinical studies
Effect of beta-adrenergic receptor blockade with propranolol on the response of plasma catecholamines and renin activity to upright tilting in normal subjects
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