Plasma protein alterations in the refractory anemia with excess blasts subtype 1 subgroup of myelodysplastic syndrome.

Proteome Science
Pavel MájekJan E Dyr

Abstract

Refractory anemia with excess blasts subtype 1 (RAEB-1) is a subgroup of myelodysplastic syndrome. It represents a heterogeneous group of oncohematological bone marrow diseases, which occur particularly in elderly patients. The aim of this proteomic study was to search for plasma protein alterations in RAEB-1 patients. A total of 24 plasma samples were depleted of fourteen high-abundant plasma proteins, analyzed with 2D SDS-PAGE, compared, and statistically processed with Progenesis SameSpots software. Proteins were identified by nanoLC-MS/MS. Retinol-binding protein 4 and leucine-rich alpha-2-glycoprotein were relatively quantified using mass spectrometry. 56 significantly differing spots were found; and in 52 spots 50 different proteins were successfully identified. Several plasma proteins that changed either in their level or modification have been described herein. The plasma level of retinol-binding protein 4 was decreased, while leucine-rich alpha-2-glycoprotein was modified in RAEB-1 patients. Changes in the inter-alpha-trypsin inhibitor heavy chain H4, altered protein fragmentation, or fragments modifications were observed. This study describes proteins, which change quantitatively or qualitatively in the plasma of RAEB...Continue Reading

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Citations

Apr 1, 1963·The American Journal of Medicine·E R MOVITTW R PORTER
Oct 9, 2015·BioMed Research International·Pavel MajekJan E Dyr
May 15, 2015·BioMed Research International·Klara PecankovaJan E Dyr
Sep 5, 2017·Cancer Biomarkers : Section a of Disease Markers·Pavel MajekJan E Dyr
Feb 27, 2015·Expert Review of Hematology·John Roboz, Gail J Roboz

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Methods Mentioned

BETA
MDS
electrophoresis
biosensors
glycosylation

Software Mentioned

MASCOT
DataAnalysis
Progenesis SameSpots

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