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Plasma protein binding interaction between phenytoin and valproic acid in vitro

British Journal of Clinical Pharmacology

Dec 1, 1978

A MonksA Richens

Abstract

1 Valproic acid or phenytoin were added to fresh human serum in varying concentrations and their binding characteristics determined by the method of Scatchard (1949). 2 Changes in serum albumin binding were investigated for phenytoin in the presence of 280, 560, 1050 and 2100 mumol l-1 ...read more

Mentioned in this Paper

Serum Albumin Measurement
ALB
Serum Proteins
Plasma Protein Binding Capacity
Protein-Protein Interaction
Binding Protein
Depakote
Site
Arginine
Plasma
Paper Details
References
  • References6
  • Citations35
1234

Plasma protein binding interaction between phenytoin and valproic acid in vitro

British Journal of Clinical Pharmacology

Dec 1, 1978

A MonksA Richens

PMID: 365209

DOI: 10.1111/j.1365-2125.1978.tb00871.x

Abstract

1 Valproic acid or phenytoin were added to fresh human serum in varying concentrations and their binding characteristics determined by the method of Scatchard (1949). 2 Changes in serum albumin binding were investigated for phenytoin in the presence of 280, 560, 1050 and 2100 mumol l-1 ...read more

Mentioned in this Paper

Serum Albumin Measurement
ALB
Serum Proteins
Plasma Protein Binding Capacity
Protein-Protein Interaction
Binding Protein
Depakote
Site
Arginine
Plasma
Paper Details
References
  • References6
  • Citations35
1234
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