Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach

Food Chemistry
Hui CaoJianbo Xiao

Abstract

Herein, the protein binding rates of structurally different flavonoids to human serum albumin (HSA) were elucidated by applying the high performance affinity chromatography (HPAC). The flavonoids with hydroxyl groups on ring A showed a higher protein binding rate compared with those that there was no hydroxyl on ring A. However, the hydroxylation of ring B lowered the protein binding rate. It was also found that an additional methoxy group in flavone ring A would decrease the protein binding rate. Nevertheless, the methoxy group in flavanone ring A (position 6) and isoflavone ring B (position 4') increased the protein binding rate. Methoxy group at other positions of flavonoids slightly enhanced or no significantly affected the binding rates on human serum albumin. Hydrogenation of C2C3 double bond of flavonoids decreased the protein binding rate and had the same effect as glycosylation which decrease the protein binding rate by 5%-25%.

Citations

Jan 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michael KaiserAndreas Schieber
Apr 21, 2020·Journal of Biomolecular Structure & Dynamics·Fahad M AlmutairiRizwan Hasan Khan
Aug 19, 2020·Food & Function·Anna Arola-ArnalAlberto Dávalos
Jun 4, 2020·Anais Da Academia Brasileira De Ciências·Ibrahim Halil Gecibesler, Murat Aydin
Nov 26, 2020·Pharmaceutics·Anallely López-YerenaElvira Escribano-Ferrer
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paweł PaśkoShela Gorinstein
Jul 15, 2021·Oxidative Medicine and Cellular Longevity·J P Jose MerlinKieran Murphy
Aug 8, 2021·Foods·Borkwei Ed NignpenseAbishek Bommannan Santhakumar
Aug 8, 2021·Scientific Reports·Aleksandra WłochEdyta Kostrzewa-Susłow
Feb 21, 2019·Journal of Agricultural and Food Chemistry·Dana M PoloniJoe A Vinson
Nov 11, 2020·Current Protein & Peptide Science·Peiyu XueLi Ren

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