Plasma proteins in fetal sheep brain: blood-brain barrier and intracerebral distribution

The Journal of Physiology
K M DziegielewskaN R Saunders

Abstract

1. Plasma proteins have been demonstrated to be present in early fetal sheep brain in amounts which cannot be accounted for by blood contamination. 2. The distribution of alpha-fetoprotein, albumin, fetuin, alpha 1-antitrypsin and transferrin has been studied by immunoassay of extracts from brain homogenates and by immunoperoxidase histochemistry of fetal brains between 37 and 125 days gestation (term is 150 days). 3. At 35 days gestation fetuin and albumin were quantitatively the most important proteins in fetal brain, both as estimated by extraction and by immunohistochemistry. Both of these proteins, and also alpha-fetoprotein and alpha 1-antitrypsin, declined considerably in amount by 60 days gestation. After 60 days the concentrations of albumin and alpha-fetoprotein were not significantly different from that due to blood contamination and only occasional cells could be demonstrated by immunohistochemistry. Fetuin and alpha 1-antitrypsin were present in reduced but significant amounts at least up to 125 days gestation. 4. The immunohistochemical results showed that considerable numbers of immature neurones were stained for some plasma proteins. Fetuin positive cells predominated both in terms of the larger number of cells ...Continue Reading

Citations

Apr 15, 2014·Experimental Biology and Medicine·Mariya S SpasovaBarbara S Stonestreet
Jan 1, 1983·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·H NewN R Saunders
Oct 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·M Matsuda
Mar 22, 1991·The Journal of Comparative Neurology·J M Rosenstein
Jan 1, 1985·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G J MarkelonisS R Max
Jan 1, 1984·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R MoroJ Uriel
Sep 13, 2016·Developmental Neurobiology·Mariya S SpasovaBarbara S Stonestreet
May 1, 1985·Journal of Neurochemistry·A Kler, A Rosen
Apr 1, 1987·Cell and Tissue Research·K M DziegielewskaN R Saunders
Sep 14, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Marie E BecknerIan F Pollack
Apr 1, 1990·Journal of Neuroscience Research·A Espinosa de los MonterosJ de Vellis
Jun 1, 2004·Experimental Biology and Medicine·Gerald J Mizejewski
Feb 19, 2011·Nature Reviews. Neuroscience·Edward A NeuweltLester R Drewes
Oct 1, 1989·Journal of Neuroscience Research·A Espinosa de los MonterosJ de Vellis
Jan 1, 1982·The International Journal of Biochemistry·A PiñeiroJ Naval
Jan 1, 1986·The International Journal of Biochemistry·J NavalA Piñeiro
Jan 1, 1983·Comparative Biochemistry and Physiology. A, Comparative Physiology·K M DziegielewskaN R Saunders
Jan 1, 1982·Comparative Biochemistry and Physiology. A, Comparative Physiology·K M Dziegielewska, N R Saunders
Feb 1, 1985·Brain Research·G FossanN R Saunders

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.