Plasma proteome in multiple sclerosis disease progression

Annals of Clinical and Translational Neurology
Arjan MalekzadehCharlotte E Teunissen

Abstract

The pathophysiology of multiple sclerosis disease progression remains undetermined. The aim of this study was to identify differences in plasma proteome during different stages of MS disease progression. We used a multiplex aptamer proteomics platform (Somalogic) for sensitive detection of 1129 proteins in plasma. MS patients were selected and categorized based on baseline and a 4-year follow-up EDSS (delta EDSS) scores; relapse-onset (RO) slow progression (n = 31), RO with rapid progression (n = 29), primary progressive (n = 30), and healthy controls (n = 20). The relation of baseline plasma protein levels with delta EDSS and different MRI progression parameters were assessed using linear regression models. Regression analyses of plasma proteins with delta EDSS showed six significant associations. Strong associations were found for the proteins LGLAS8 (P = 7.64 × 10-5 , q = 0.06), CCL3 (P = 0.0001, q = 0.06), and RGMA (P = 0.0005, q = 0.09). In addition, associations of plasma proteins were found with percentage brain volume for C3 (P = 2,08 × 10-9 , q = 1,70 × 10-6 ), FGF9 (P = 3,42 × 10-9 , q = 1,70 × 10-6 ), and EHMT2 (P = 0.0007, q = 0.01). Most of the significant markers were associated with cell-cell and cell-extracellul...Continue Reading

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Citations

Mar 23, 2021·In Vitro Cellular & Developmental Biology. Animal·Alinne do Carmo CostaErika Cristina Jorge
May 18, 2021·BioMed Research International·Jinhua TangJun Yang
May 22, 2021·Biomarker Insights·Ameneh JafariMostafa Rezaei-Tavirani
Jun 30, 2021·Clinical Proteomics·Angelique Florentinus-MefailoskiJohn G Marshall

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Software Mentioned

Limma
AMIRA
String
package
SPSS
SIENA
Venny
R
SOMAscan

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