Plasma proteomic profiling in HIV-1 infected methamphetamine abusers.

PloS One
Gwenael PottiezPawel Ciborowski

Abstract

We wanted to determine whether methamphetamine use affects a subset of plasma proteins in HIV-infected persons. Plasma samples from two visits were identified for subjects from four groups: HIV+, ongoing, persistent METH use; HIV+, short-term METH abstinent; HIV+, long term METH abstinence; HIV negative, no history of METH use. Among 390 proteins identified, 28 showed significant changes in expression in the HIV+/persistent METH+ group over the two visits, which were not attributable to HIV itself. These proteins were involved in complement, coagulation pathways and oxidative stress. Continuous METH use is an unstable condition, altering levels of a number of plasma proteins.

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Sep 21, 2013·Journal of Neuroinflammation·Thangavel SamikkannuMadhavan P N Nair
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May 9, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sunitha KodidelaSantosh Kumar

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Methods Mentioned

BETA
flow cytometry
X-ray
proteomic profiling

Software Mentioned

[UNK]

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