Plasma proteomic profiling suggests an association between antigen driven clonal B cell expansion and ME/CFS.

PloS One
Milica MilivojevicW Ian Lipkin

Abstract

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an unexplained chronic, debilitating illness characterized by fatigue, sleep disturbances, cognitive dysfunction, orthostatic intolerance and gastrointestinal problems. Using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), we analyzed the plasma proteomes of 39 ME/CFS patients and 41 healthy controls. Logistic regression models, with both linear and quadratic terms of the protein levels as independent variables, revealed a significant association between ME/CFS and the immunoglobulin heavy variable (IGHV) region 3-23/30. Stratifying the ME/CFS group based on self-reported irritable bowel syndrome (sr-IBS) status revealed a significant quadratic effect of immunoglobulin lambda constant region 7 on its association with ME/CFS with sr-IBS whilst IGHV3-23/30 and immunoglobulin kappa variable region 3-11 were significantly associated with ME/CFS without sr-IBS. In addition, we were able to predict ME/CFS status with a high degree of accuracy (AUC = 0.774-0.838) using a panel of proteins selected by 3 different machine learning algorithms: Lasso, Random Forests, and XGBoost. These algorithms also identified proteomic profiles that predicted ...Continue Reading

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Citations

Feb 3, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Peter L ToogoodDavid Hoffman
Apr 2, 2021·Brain, Behavior, and Immunity·Wakiro SatoTakashi Yamamura
Jun 29, 2021·Current Neurology and Neuroscience Reports·Narges MoghimiAfshin A Divani
Jul 16, 2021·The Journal of Clinical Investigation·Øystein FlugeOlav Mella

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Methods Mentioned

BETA
proteomics assay

Software Mentioned

Matlab
XGBoost
R
Lasso
Random

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