Plasma proteomic signature of the risk of developing mobility disability: A 9-year follow-up.

Aging Cell
Yusuke OsawaLuigi Ferrucci

Abstract

Mobility disability is a powerful indicator of poor health in older adults. The biological and pathophysiological mechanism underlying the development of mobility disability remains unknown. This study conducted a data-driven discovery phase investigation to identify plasma proteins that predict the incidence of mobility disability in community-dwelling older adults without mobility disability at baseline. We investigated 660 women and men, aged 71.9 ± 6.0 (60-94) years, who participated in the Invecchiare in Chianti, "Aging in the Chianti Area" study and completed the 400-m walk at fast pace (400-m walk) at enrollment. Median follow-up time was 8.57 [interquartile, 3.20-9.08] years. SOMAscan technology was used to measure 1,301 plasma proteins at enrollment. The incident of mobility disability was defined as inability to complete the 400-m walk. Protein-specific Cox proportional hazard model was adjusted for sex, age, and other important covariates. Plasma levels of 75 proteins predicted mobility disability (p < .05). Significant proteins were enriched for the KEGG "PI3K-Akt signaling," "phagosomes," and "cytokine-cytokine receptor interaction" pathways. After multiple comparison adjustment, plasma cathepsin S (CTSS; hazard ra...Continue Reading

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Citations

Jul 3, 2020·Diabetes & Metabolism Journal·Joon Young ChangMinho Shong
Jan 12, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Juliette TavenierJan O Nehlin
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Oct 8, 2021·Journal of Cachexia, Sarcopenia and Muscle·Julian AlcazarCharlotte Suetta

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Methods Mentioned

BETA
acid dissociation

Software Mentioned

Shiny
SOMAscan
SAS
SASP Atlas

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