Plasma renin activity and in vitro synthesis of aldosterone by the adrenal glands of rats with spontaneous, renal, or pinealectomy-induced hypertension

Acta Physiologica Scandinavica
H KarppanenH Vapaatalo

Abstract

In the present study a comparison was made on the role of the renin-aldosterone system in rats with various forms of experimental hypertension (pinealectomy-induced, renal and spontaneous). The plasma sodium and potassium concentrations as well as renin activity were measured. The in vitro production of aldosterone by quartered adrenal glands of these rats was also determined. 5 weeks after the operations the blood pressure of the pinealectomized and renal operated rats was significantly increased. The plasma sodium concentration did not differ in various groups, but that of potassium was decreased in the renal hypertensive animals. The plasma renin activity of the pinealectomized rats was elevated while in other forms of hypertension it was at the control level. The basal aldosterone production by the adrenal quarters was equal in all the groups. ACTH, dibutyryl cyclic adenosine-3',5'-monophosphate (DBA) and 5HT stimulated the aldosterone production. The responses to ACTH and DBA were greater in the adrenals of renal hypertensive rats than in the other forms of hypertension or in the controls. We suggest that the renin-aldosterone system is of importance in the maintenance of renal hypertension, while in pinealectomy-induced h...Continue Reading

References

Feb 1, 1973·The Journal of Pharmacy and Pharmacology·P A van Zwieten
Jan 15, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·H Karppanen
Jan 1, 1970·Pharmacology·H KarppanenM K Paasonen
Jan 1, 1971·The American Journal of Physiology·A Birbari
Dec 1, 1971·Circulation Research·D T PalsD C Fessler
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·H C Erbler
Dec 1, 1972·Circulation Research·S SenF M Bumpus
Apr 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·W De JongA Sjoerdsma
Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI
Apr 1, 1949·Proceedings of the Society for Experimental Biology and Medicine·M FRIEDMAN, S C FREED

Citations

Jan 1, 1985·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·A J AhoR Paul
May 18, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E KilicT Dalkara
Nov 21, 2008·Clinical and Experimental Pharmacology & Physiology·Hua-Li LiHua Zhao
Feb 1, 1980·Clinical and Experimental Hypertension : CHE·K KawashimaH Sokabe
Oct 1, 1993·Journal of Pineal Research·Y SongS F Pang
Jul 17, 2010·Annals of the New York Academy of Sciences·Gregory F Oxenkrug, Paul Summergrad
Feb 1, 2013·International Journal of Hypertension·Luciana A CamposOvidiu C Baltatu
May 1, 1985·Acta Physiologica Scandinavica·B Uvelius, E Rosengren
Aug 20, 2014·PM & R : the Journal of Injury, Function, and Rehabilitation·Andrei Krassioukov, Christopher West
Mar 22, 2014·Journal of the American Society of Nephrology : JASN·Natsuko TokonamiDmitri Firsov
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Q YangS T O'Rourke

Related Concepts

Phosphaden
Adrenal Glands
Corticotropin
Aldosterone, (11 beta,17 alpha)-Isomer
Diastolic Blood Pressure
Hypertensive Disease
Renal Hypertension
Pineal Gland
Potassium
Preprorenin

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