Plasma renin activity and in vitro synthesis of aldosterone by the adrenal glands of rats with spontaneous, renal, or pinealectomy-induced hypertension

Acta Physiologica Scandinavica
H KarppanenH Vapaatalo


In the present study a comparison was made on the role of the renin-aldosterone system in rats with various forms of experimental hypertension (pinealectomy-induced, renal and spontaneous). The plasma sodium and potassium concentrations as well as renin activity were measured. The in vitro production of aldosterone by quartered adrenal glands of these rats was also determined. 5 weeks after the operations the blood pressure of the pinealectomized and renal operated rats was significantly increased. The plasma sodium concentration did not differ in various groups, but that of potassium was decreased in the renal hypertensive animals. The plasma renin activity of the pinealectomized rats was elevated while in other forms of hypertension it was at the control level. The basal aldosterone production by the adrenal quarters was equal in all the groups. ACTH, dibutyryl cyclic adenosine-3',5'-monophosphate (DBA) and 5HT stimulated the aldosterone production. The responses to ACTH and DBA were greater in the adrenals of renal hypertensive rats than in the other forms of hypertension or in the controls. We suggest that the renin-aldosterone system is of importance in the maintenance of renal hypertension, while in pinealectomy-induced h...Continue Reading


Feb 1, 1973·The Journal of Pharmacy and Pharmacology·P A van Zwieten
Jan 15, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·H Karppanen
Jan 1, 1970·Pharmacology·H KarppanenM K Paasonen
Jan 1, 1971·The American Journal of Physiology·A Birbari
Dec 1, 1971·Circulation Research·D T PalsD C Fessler
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·H C Erbler
Dec 1, 1972·Circulation Research·S SenF M Bumpus
Apr 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·W De JongA Sjoerdsma
Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI
Apr 1, 1949·Proceedings of the Society for Experimental Biology and Medicine·M FRIEDMAN, S C FREED


Jan 1, 1985·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·A J AhoR Paul
May 18, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E KilicT Dalkara
Nov 21, 2008·Clinical and Experimental Pharmacology & Physiology·Hua-Li LiHua Zhao
Feb 1, 1980·Clinical and Experimental Hypertension : CHE·K KawashimaH Sokabe
Oct 1, 1993·Journal of Pineal Research·Y SongS F Pang
Jul 17, 2010·Annals of the New York Academy of Sciences·Gregory F Oxenkrug, Paul Summergrad
Feb 1, 2013·International Journal of Hypertension·Luciana A CamposOvidiu C Baltatu
May 1, 1985·Acta Physiologica Scandinavica·B Uvelius, E Rosengren
Aug 20, 2014·PM & R : the Journal of Injury, Function, and Rehabilitation·Andrei Krassioukov, Christopher West
Mar 22, 2014·Journal of the American Society of Nephrology : JASN·Natsuko TokonamiDmitri Firsov
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Q YangS T O'Rourke

Related Concepts

Adrenal Glands
Aldosterone, (11 beta,17 alpha)-Isomer
Diastolic Blood Pressure
Hypertensive Disease
Renal Hypertension
Pineal Gland

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.