Plasma renin activity and urinary aldosterone in acromegaly

Journal of Endocrinological Investigation
F ManteroM Muggeo

Abstract

The behaviour of the renin-angiotensin-aldosterone system was evaluated in 16 acromegalic patients, of whom 7 were hypertensive. The patients were studied in basal conditions, after suppression with 9alpha-fluorohydrocortisone, and after stimulation with furosemide. Baseline and after furosemide PRA were significantly lower in acromegalic hypertensive patients than in the normotensive group. Mean urinary aldosterone excretion was found at the upper limits of the normal range; it was occasionally elevated, but the values were not satistically different in the two groups. There was a suppression after 9 alpha fluorohydrocortisone in both groups, though it did not reached the 50%. These data show that there is a disorder of the renin-angiotensin-aldosterone system in acromegalic subjects. This defective regulation is sometimes similar to that present in primary aldosteronism. In fact in two patients a typical phlebographic and scintigraphic picture of primary aldosteronism has been found; surgery, performed in both patients, revealed a large cortical adenoma in one case and a macronodular hyperplasia in the second case. However, the relationship between this adrenal abnormalities and hypertension in acromegaly are not yet complete...Continue Reading

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Citations

Dec 1, 1989·Clinical Endocrinology·R FraserJ M Connell
Sep 13, 2008·Journal of Endocrinological Investigation·C ScaroniF Mantero
Sep 12, 2014·F1000Research·Joanna MatrozovaSabina Zacharieva
Nov 17, 1989·Klinische Wochenschrift·R GriebenowW Winkelmann
May 9, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jens Møller
Jan 18, 2006·Biochemical and Biophysical Research Communications·Shiro YoshiokaKazuo Chihara

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