Abstract
It has been established that angiotensin II stimulation may limit the antihypertensive potential of diuretic therapy in some patients. It is less clear, however, whether renin-angiotensin II stimulation is the cause of the flat blood pressure dose-response relationship to diuretics. To investigate this, 75 out-patients with essential hypertension were treated with chlorthalidone 12.5, 25 or 50 mg o.d. for 3 weeks, in a double-blind, placebo controlled cross-over study. Chlorthalidone significantly reduced blood pressure in all the groups, a plateau being reached at 25 mg o.d. Similarly, plasma renin activity was increased by each dose level of chlorthalidone, but it showed a different trend, being increased to a comparable extent at 12.5 mg and 25 mg o.d., and still higher at 50 mg o.d. Thus, greater stimulation of renin was coincident with the levelling of the blood pressure response to chlorthalidone. However no significant correlation was found between interindividual plasma renin activity and change in blood pressure, either in the entire series, or in each treatment subset. The data suggest overall that renin stimulation may influence the characteristic dose-hypotensive response relationship to diuretic agents in antihyper...Continue Reading
References
Feb 2, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·R MalvanoA Salvetti
Dec 1, 1978·Clinical Science and Molecular Medicine. Supplement·G LeonettiA Zanchetti
Nov 1, 1977·Clinical Pharmacology and Therapeutics·M G TweeddaleJ Ruedy
Aug 1, 1978·Clinical Pharmacology and Therapeutics·B J MatersonJ Morledge
Mar 1, 1978·Circulation Research·E D VaughanC R Ayers
Aug 1, 1977·Annals of Internal Medicine·G H AndersonD H Streeten
Nov 1, 1977·Annals of Internal Medicine·M A WeberJ H Laragh
Jan 25, 1975·British Medical Journal·C BengtssonL Werkö
Jun 1, 1976·Archives of Internal Medicine·H J KeimJ H Laragh
Nov 1, 1970·The Journal of Clinical Investigation·H R BrunnerJ H Laragh
Jan 1, 1969·Diseases of the Chest·G MuiesanM Motolese
Aug 1, 1972·The Journal of Clinical Investigation·R G DluhyG H Williams
May 14, 1983·British Medical Journal·G A MacGregorJ Roulston
Mar 6, 1982·British Medical Journal·G A MacGregorJ C Jones
Jan 1, 1981·European Journal of Clinical Pharmacology·J C RoosE J Dorhout Mees
Jan 1, 1981·European Journal of Clinical Pharmacology·J G RussellI S Humphries
Citations
Mar 28, 2006·Journal of the American Society of Nephrology : JASN·Antonio Salvetti, Lorenzo Ghiadoni
Oct 10, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Wentian Li, Pedro Miramontes
Feb 23, 2011·The British Journal of Nutrition·Akira ShimotoyodomeTadashi Hase
Jul 1, 1989·The Journal of International Medical Research·E BichisaoG Pollavini