Plasma rich in growth factors eye drops to treat secondary ocular surface disorders in patients with glaucoma

International Medical Case Reports Journal
Ronald M Sanchez-AvilaEduardo Anitua

Abstract

To evaluate the efficacy and safety of plasma rich in growth factors (PRGF) eye drops in patients with glaucoma with secondary ocular surface disorders (OSDs) due to surgeries and topical hypotensive drugs use. A retrospective case-series study design was used including six patients (eight eyes) diagnosed with glaucoma who received surgical (nonpenetrating deep sclerectomy and/or trabeculectomy) and medical treatments (hypotensive eye drops) to control intraocular pressure (IOP) and who developed secondary OSDs, unresponsive to conventional treatments. Patients were treated with PRGF eye drops (four times a day). Outcome measures were ocular surface disease index (OSDI), best-corrected visual acuity (BCVA, in logarithm of the minimum angle of resolution), visual analog scale (VAS), frequency and severity of symptoms, and IOP. The safety of the treatment was also evaluated. Six patients (seven eyes with open-angle glaucoma and one eye with uveitic glaucoma) treated with PRGF eye drops were evaluated. Mean age was 71 years (SD=7.2, range 58-79 years). Five were female and one was male. The mean treatment time was 21.8 weeks (SD=9.0, range 12-36 weeks). The mean time to reach closure of the corneal ulcer was 14.5 (SD=5.5) weeks. A...Continue Reading

Citations

Jul 2, 2020·Clinical Ophthalmology·Borja de la Sen-CorcueraJesús Merayo-Lloves
Sep 19, 2020·Cornea·Eduardo AnituaJesús Merayo-Lloves
Dec 17, 2020·Asia-Pacific Journal of Ophthalmology·Lisa M NijmMinas Theodore Coroneo
Oct 30, 2020·Clinical Ophthalmology·Jingjing YouGerard Sutton
Oct 15, 2020·International Journal of Molecular Sciences·Carlota Suárez-BarrioJesús Merayo-Lloves
Jul 20, 2021·Expert Opinion on Biological Therapy·E AnituaJ Merayo-Lloves

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