Plasma S100A8/A9 heterodimer is an early prognostic marker of acute kidney injury associated with cardiac surgery.

Biomarkers in Medicine
Zacharoula NikolakopoulouAnne Burke-Gaffney

Abstract

We investigated whether plasma levels of the inflammation marker S100A8/A9, could predict acute kidney injury (AKI) onset in patients undergoing cardiac surgery necessitating cardiopulmonary bypass (CPB). Plasma levels of S100A8/A9 and other neutrophil cytosolic proteins were measured in 39 patients pre- and immediately post-CPB. All markers increased significantly post-CPB with S100A8/A9, S100A12 and myeloperoxidase levels significantly higher in patients who developed AKI within 7 days. S100A8/A9 had good prognostic utility for AKI, with an area under the receiver operating characteristic curve of 0.81 (95% CI: 0.676-0.949) and a cut-off value of 10.6 μg/ml (85.7% sensitivity and 75% specificity) irrespective of age. Plasma S100A8/A9 levels immediately after cardiac surgery, can predict onset of AKI, irrespective of age.

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Citations

Sep 26, 2020·Frontiers in Medicine·Vikram SabapathyRahul Sharma
Nov 20, 2020·Antioxidants·Lisanne BoekhoudHjalmar R Bouma
Aug 18, 2021·Biological Trace Element Research·Di WangRui Wu

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Methods Mentioned

BETA
coronary artery bypass
ELISA
lavage

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Prism
Excel

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