PMID: 6411159Jul 1, 1983Paper

Plasma serine to cysteine ratio as a biological marker for psychosis

The British Journal of Psychiatry : the Journal of Mental Science
R WaziriA Sherman

Abstract

In a study of plasma amino acids in psychiatric patients, serine to cysteine (S/C) ratio was higher (S/C = 1.57 +/- 0.28) in 57 psychotics compared to 27 nonpsychotics (S/C = 1.06 +/- 0.23). This difference was highly significant at P less than 0.001. Psychotic patients were given a psychosis score (p score) of 1-4. The S/C ratios of individual patients were significantly correlated to their p scores (r = 0.65, P less than 0.001). S/C ratios were not related to diagnosis, age, sex, food intake and medications. When the initial S/C ratio and p scores of 22 patients were compared to their S/C ratio and p score at the time when they were improved and ready to be discharged, there was a concomitant fall both in S/C ratios and p scores suggesting the high S/C ratios may be indicative of a state rather than a trait characteristic. Our findings lead us to the conclusion that S/C ratios may provide a marker for the presence of psychosis and an index of its severity.

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Citations

Jan 1, 1987·European Archives of Psychiatry and Neurological Sciences·R Waziri, J Mott
May 9, 2006·Experimental Brain Research·Kaneez Fatima Shad
Jun 1, 1992·Biological Psychiatry·G F CarlB K Young
Aug 15, 1993·Biological Psychiatry·E J Devor, R Waziri
Jun 1, 1984·Psychiatry Research·R WaziriJ Mott
Jun 1, 1985·Psychiatry Research·T L Perry, S Hansen
Jun 1, 1986·Psychiatry Research·R Waziri, J Mott
Apr 1, 1990·Psychiatry Research·F MacciardiE Smeraldi
May 17, 1996·Psychiatry Research·R WaziriL Christensen
Nov 1, 1989·Medical Hypotheses·E P Heleniak, D M Frechen
Jan 1, 1993·Schizophrenia Research·R WaziriA D Sherman
Jan 1, 1995·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·C AltamuraH Y Meltzer
Sep 1, 1985·Journal of Affective Disorders·R WaziriJ Wilcox
Dec 1, 1987·Acta Psychiatrica Scandinavica·M T Yasamy
Jan 1, 1985·Biological Psychiatry·R Waziri
Jul 16, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Toru NakamuraHeii Arai
Sep 11, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tohru Ohnuma, Heii Arai
Sep 1, 1984·The British Journal of Psychiatry : the Journal of Mental Science·G Winokur

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