Plasma small ncRNA pair panels as novel biomarkers for early-stage lung adenocarcinoma screening

BMC Genomics
Yuhong DouYouping Deng

Abstract

Lung cancer is a major cause of cancer-related mortality worldwide, and around two-thirds of patients have metastasis at diagnosis. Thus, detecting lung cancer at an early stage could reduce mortality. Aberrant levels of circulating small non-coding RNAs (small ncRNAs) are potential diagnostic or prognostic markers for lung cancer. We aimed to identify plasma small ncRNA pairs that could be used for early screening and detection of lung adenocarcinoma (LAC). A panel of seven small ncRNA pair ratios could differentiate patients with LAC or benign lung disease from high-risk controls with an area under the curve (AUC) of 100.0%, a sensitivity of 100.0% and a specificity of 100.0% at the training stage (which included 50 patients with early-stage LAC, 35 patients with benign diseases and 29 high-risk controls) and an AUC of 90.2%, a sensitivity of 91.5% and a specificity of 80.4% at the validation stage (which included 44 patients with early-stage LAC, 32 patients with benign diseases and 51 high-risk controls). The same panel could distinguish LAC from high-risk controls with an AUC of 100.0%, a sensitivity of 100.0% and a specificity of 100.0% at the training stage and an AUC of 89.5%, a sensitivity of 85.4% and a specificity of...Continue Reading

References

Dec 25, 2002·European Journal of Radiology·C J Beadsmoore, N J Screaton
Oct 6, 2005·Journal of the National Cancer Institute·Brenda K EdwardsLinda W Pickle
Oct 27, 2006·The New England Journal of Medicine·UNKNOWN International Early Lung Cancer Action Program InvestigatorsOlli S Miettinen
Mar 8, 2007·JAMA : the Journal of the American Medical Association·Peter B BachColin B Begg
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Oct 15, 2008·Nature Reviews. Genetics·Alex S Flynt, Eric C Lai
Sep 15, 2009·Gut·Aaron J Schetter, Curtis C Harris
Dec 26, 2009·Biochemical and Biophysical Research Communications·Yanqin SunLinlang Guo
Feb 12, 2010·Methods : a Companion to Methods in Enzymology·Evan M KrohMuneesh Tewari
Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Mattia BoeriGabriella Sozzi
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Lei YuFeng Jiang
May 26, 2011·Nucleic Acids Research·Andrey TurchinovichBarbara Burwinkel
Jan 14, 2012·British Journal of Cancer·R J BryantF C Hamdy
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
Mar 13, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pablo Perez-MorenoJean-Charles Soria
Aug 29, 2012·International Journal of Cancer. Journal International Du Cancer·Katarina CukBarbara Burwinkel
Dec 4, 2012·Nucleic Acids Research·Travis J WheelerRobert D Finn
Jan 22, 2013·Briefings in Bioinformatics·Vernell WilliamsonVladimir Vladimirov
Mar 9, 2013·Future Oncology·Martina RedovaOndrej Slaby
Jun 19, 2013·Nucleic Acids Research·David T Humphreys, Catherine M Suter
Aug 16, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Riccardo CazzoliHarvey I Pass
Nov 28, 2013·Nucleic Acids Research·Ana Kozomara, Sam Griffiths-Jones
Dec 11, 2013·JAMA Internal Medicine·Edward F PatzUNKNOWN NLST Overdiagnosis Manuscript Writing Team
Jan 15, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gabriella SozziUgo Pastorino
Feb 4, 2014·International Journal of Cancer. Journal International Du Cancer·Jie HuJiping Wang
Feb 5, 2014·Nature Reviews. Clinical Oncology·Heidi SchwarzenbachKlaus Pantel
Mar 13, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Orazio FortunatoGabriella Sozzi
Jun 24, 2014·Source Code for Biology and Medicine·Chuming ChenCathy H Wu
Aug 16, 2014·Virchows Archiv : an International Journal of Pathology·Mi Kyeong KimHyoun Wook Lee
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Sep 25, 2020·BMC Medical Informatics and Decision Making·Xiaoli ChenYouping Deng
Aug 24, 2021·Frontiers in Oncology·Yong ZhuYouping Deng

❮ Previous
Next ❯

Methods Mentioned

BETA
ncRNA
Assay
PCR
smRNA-seq

Software Mentioned

WEKA
SPSS
Cufflinks
tie
Bow
CASAVA
Bowtie

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.