PMID: 8611474Apr 1, 1996Paper

Plasma soluble interleukin-2 receptor level in patients with primary myelodysplastic syndromes: a relationship with disease subtype and clinical outcome

British Journal of Haematology
K OgataT Nomura

Abstract

To assess the hypothesis that the plasma soluble interleukin-2 receptor (sIL-2R) level may have predictive value for morbidity/mortality in patients with myelodysplastic syndromes (MDS), we determined in plasma sIL-2R level of 80 MDS patients and examined their subsequent clinical course. Compared with low-risk MDS (refractory anaemia (RA) and RA with ringed sideroblasts) patients and normal subjects, the plasma sIL-2R level was significantly elevated in high-risk MDS (three other MDS subtypes and acute leukaemia following MDS) patients (high-risk MDS versus low-risk MDS, P < 0.01; high-risk MDS versus normal subjects, P < 0.01). 14/40 low-risk MDS patients developed at least one of the following during the follow-up period: erythrocyte transfusion dependence, infections requiring hospitalization, disease progression or MDS-related death. The plasma sIL-2R level was higher in these eventful subjects than in event-free low-risk subjects (P < 0.0001), and all of 10 low-risk subjects with a plasma sIL-2R level > 540 U/ml experience at least one event. By logistic regression analysis of various parameters in these 40 low-risk subjects, the plasma sIL-2R level was identified as the strongest independent parameter for predicting even...Continue Reading

Citations

Sep 22, 1998·The Journal of Experimental Medicine·A E MayK T Preissner
Jul 12, 2003·Leukemia & Lymphoma·Shigeo HoriikeMasafumi Taniwaki
May 9, 2007·Leukemia Research·Yumiko ShioiKiyoyuki Ogata
Jan 16, 2007·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Kiyoyuki Ogata

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