Plasma sRAGE is not associated with urinary microalbumin excretion in type 2 diabetic nephropathy at the early stage

Diabetes Research and Clinical Practice
Jiang-Yi YuFeng Gao

Abstract

The interaction of advanced glycation end products (AGEs) and the receptor for advanced glycation end products (RAGE) has played an important role in the pathogenesis of diabetic nephropathy. In the present study, we measured the relationship of plasma soluble isoform of RAGE (sRAGE) and urinary microalbumin excretion in the early stage of type 2 diabetic nephropathy. 180 patients with early stage of type 2 diabetic nephropathy were recruited into the study. Plasma sRAGE and the characterized AGE carboxymethyllysine (CML) were measured by enzyme-linked immunosorbent assay. Plasma sRAGE positively correlated with the level of CML (R=0.22, P=0.03) while sRAGE was not significantly correlated with the urinary mAlb/Cr (R=0.15, P=NS). On stepwise linear regression analysis, AGE and GFR were the main independent determinants of plasma sRAGE concentration. Plasma sRAGE is not significantly associated with urinary microalbumin excretion in the early stage of diabetic nephropathy while it is correlated positively with circulating AGE and negatively with glomerular filtration rate (GFR).

References

May 19, 1988·The New England Journal of Medicine·M BrownleeH Vlassara
Aug 31, 2000·Journal of the American Society of Nephrology : JASN·Nozomu TanjiVivette D D'Agati
Sep 24, 2004·The Journal of Biological Chemistry·Lana E HanfordTim D Oury
Dec 24, 2004·Diabetes Care·Jorge L GrossThemis Zelmanovitz
Jun 3, 2005·Journal of the American Society of Nephrology : JASN·Josephine M ForbesMark E Cooper
May 25, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Sho-ichi Yamagishi, Tsutomu Imaizumi
Mar 12, 2008·Current Molecular Medicine·Hiroshi YamamotoNaho Murakami
May 14, 2008·Current Pharmaceutical Design·Kazuhiro SugimotoSoroku Yagihashi
Jul 12, 2008·Archives of Physiology and Biochemistry·Katerina KankováTomás Zima
Jan 6, 2009·Diabetes Care·UNKNOWN American Diabetes Association

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