Abstract
Soluble urokinase plasminogen activator receptor (suPAR) is a stable inflammatory biomarker. In patients, suPAR is a marker of disease presence, severity and prognosis. In the general population, suPAR is predictive of disease development, such as diabetes and cardiovascular disease and, in smokers, predictive of long-term lung cancer development. Whether smoking cessation impacts the suPAR level is unknown. Forty-eight smokers were randomized into three groups of 16: (i) continued to smoke 20 cigarettes per day, (ii) refrained from smoking and used transdermal nicotine patches and (iii) refrained from smoking and used placebo patches. Nonsmokers were included for comparison. suPAR and C-reactive protein (CRP) levels were measured by ELISA. At baseline, the suPAR level was significantly higher in the 48 smokers (median 3·2 ng mL, IQR (2·5-3·9)) than in 46 never smokers (1·9 ng/mL (1·7-2·2)). In smokers randomized to smoking cessation, suPAR levels after 4 weeks of stopping were decreased and no longer significantly different from the never smokers values. SuPAR decreased in both those who received a placebo as well as nicotine patch. Interestingly, those with the highest suPAR level at time of smoking were also those with the h...Continue Reading
References
Jun 16, 2000·FEBS Letters·N SideniusF Blasi
May 13, 2006·Clinical Chemistry·Kristian KofoedJesper Eugen-Olsen
May 29, 2007·Journal of the American College of Cardiology·Paul M Ridker
Dec 22, 2007·Journal of Medical Virology·Ove AndersenSteen B Haugaard
Dec 29, 2009·FEBS Letters·Francesco Blasi, Nicolai Sidenius
Jan 9, 2010·European Journal of Clinical Investigation·I SimeraD G Altman
Mar 30, 2010·Surgery·Lars Tue SørensenFinn Gottrup
Aug 1, 2007·Biomarkers in Medicine·David Conen, Paul M Ridker
Jun 22, 2010·Journal of Internal Medicine·J Eugen-OlsenS B Haugaard
Jan 18, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anne LangkildeJesper Eugen-Olsen
Mar 4, 2011·Journal of Internal Medicine·Jesper Eugen-Olsen
Mar 31, 2012·International Journal of Cardiology·Stig LyngbækJørgen Jeppesen
Jul 25, 2012·Critical Care : the Official Journal of the Critical Care Forum·Thomas Huneck HauptOve Andersen
Aug 23, 2012·International Journal of Cardiology·Stig LyngbækJørgen Jeppesen
Oct 15, 2013·Journal of Critical Care·Katia DonadelloJean-Louis Vincent
Nov 21, 2013·Stroke; a Journal of Cerebral Circulation·Margaretha PerssonGunnar Engström
Mar 1, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Alexander KochFrank Tacke
Mar 22, 2014·Journal of Internal Medicine·R B RaggamM Hoenigl
Sep 5, 2014·Journal of Clinical Microbiology·M ReichsoellnerM Hoenigl
Oct 3, 2014·Journal of the National Cancer Institute·Meredith S ShielsAnil K Chaturvedi
Oct 21, 2014·PloS One·Eva HaastrupHenrik Ullum
Oct 25, 2014·Journal of the American Heart Association·Danny J EapenArshed A Quyyumi
Jan 13, 2015·Biomarker Insights·Thomas H HauptJesper Eugen-Olsen
Jun 30, 2015·The Canadian Journal of Cardiology·Gethin W HodgesJørgen L Jeppesen
Citations
Jan 14, 2017·Critical Reviews in Clinical Laboratory Sciences·S DesmedtM M Speeckaert
May 10, 2018·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Line Jee Hartmann RasmussenAvshalom Caspi
May 3, 2018·Journal of the American Heart Association·Salim S HayekBarry I Freedman
Sep 5, 2018·Postgraduate Medical Journal·Lamiaa HamieMazen Kurban
Nov 6, 2018·World Journal of Surgery·Morten AlstrupKasper Iversen
Jan 11, 2019·The British Journal of Nutrition·Peter B S TörnkvistJesper Eugen-Olsen
Nov 16, 2019·Respiratory Research·K E J HåkanssonCharlotte Suppli Ulrik
May 14, 2020·Scandinavian Cardiovascular Journal : SCJ·Gethin HodgesCasper N Bang
Apr 21, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Kjell E J HåkanssonLine J H Rasmussen
Aug 9, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Line Jee Hartmann RasmussenTerrie E Moffitt
Nov 8, 2017·Disease Markers·Yuli HuangYunzhao Hu
Mar 2, 2019·Lung·Renáta M BöcskeiAndrás Bikov
Aug 29, 2018·Scientific Reports·Silvano GallusUgo Pastorino
Nov 4, 2017·The Journal of Infectious Diseases·Ditte M Kirkegaard-KlitboThomas Benfield
Sep 24, 2020·Scientific Reports·Rafal N WlazelTomasz Kostka
Mar 26, 2021·Scientific Reports·Isabel DrakeMarju Orho-Melander
May 22, 2021·Journal of Medical Virology·Buğra KergetLeyla Sağlam
Jun 4, 2021·Communications Biology·Joseph DowsettHenrik Ullum
Jun 21, 2020·Drug Discovery Today·Daniele D'AlonzoVincenzo Pavone
Dec 21, 2021·Frontiers in Immunology·Line Jee Hartmann RasmussenJesper Eugen-Olsen