Plasma Surface Functionalized Polyetheretherketone for Enhanced Osseo-Integration at Bone-Implant Interface

ACS Applied Materials & Interfaces
Ying ZhaoK W K Yeung

Abstract

This study aims at improving osseo-integration at the bone-implant interface of polyetheretherketone (PEEK) by water (H2O) and ammonia (NH3) plasma immersion ion implantation (PIII). The pertinent surface characteristics including surface energy, roughness, morphology, and chemical composition are investigated systematically and the in vitro biological performance is evaluated by cell adhesion and proliferation, alkaline phosphatase (ALP) activity, real-time RT-PCR evaluation, and mineralization tests. In vivo osseo-integration is examined via implanting samples into the distal femur of the rats. The hydrophilicity, surface roughness, cell adhesion, and proliferation, ALP activity, and osteogenic differentiation after H2O PIII or NH3 PIII are improved significantly. Furthermore, substantially enhanced osseo-integration is achieved in vivo. Nonline-of-sight plasma surface functionalization, which is particularly suitable for biomedical implants with an irregular geometry, does not alter the bulk compressive yield strength and elastic modulus of the materials. Consequently, the favorable bulk attributes of PEEK are preserved while the surface biological properties are enhanced thus boding well for wider orthopedic application of ...Continue Reading

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Citations

May 2, 2017·ACS Applied Materials & Interfaces·Monika Golda-CepaAndrzej Kotarba
May 17, 2018·Journal of Biomaterials Science. Polymer Edition·Chunyan WangZhi-Gang Chen
Sep 5, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qinwen ChengXingdong Zhang
Feb 13, 2018·Biomaterials Science·Chen LiPeng Yang
Oct 14, 2019·Journal of Biomedical Materials Research. Part a·Yu ZhuHong-Chang Lai
May 10, 2019·APL Bioengineering·Edgar A WakelinAnthony S Weiss
Sep 2, 2020·The Journal of the American Academy of Orthopaedic Surgeons·Daniel PossleyJad G Khalil
Jan 30, 2021·Frontiers in Bioengineering and Biotechnology·Xinming GuYanmin Zhou
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Tianjie ChenHong Liu

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