PMID: 15374135Jan 1, 1997Paper

Plasma thrombomodulin values and hepatorenal function in the elderly

Archives of Gerontology and Geriatrics
A DeguchiK Deguchi

Abstract

To define the clinical significance of plasma thrombomodulin (TM) values in elderly, we examined plasma TM in healthy young subjects, healthy elderly subjects and patients with cerebral infarction sequelae. We also studied the relationship with effective renal plasma flow (ERPF) and with the liver's protein-production ability. The TM values of healthy elderly subjects were higher than those of healthy young subjects. There existed an inverse correlation between TM values and ERPF. Accordingly, high TM values might significantly influence renal arteriosclerosis. From the inverse correlation identified between TM and serum cholinesterase, it was estimated that high TM might appear in conjunction with the liver's protein production ability. Patients with cerebral infarction showed higher plasma TM values. It is thought that angiopathy has been maintained in patients as the anamnesis of cerebral infarction even though it occurred in the past. The TM values of patients with diabetes mellitus (DM) were higher than those without it. Moreover, the TM values of patients with DM complicated by retinopathy were higher than those uncomplicated by retinopathy. It is therefore estimated that increased TM might occur with angiopathy resulting...Continue Reading

References

Mar 1, 1991·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·A DeguchiH Ishii
Oct 1, 1991·American Journal of Hematology·K DeguchiK Tanaka
Dec 1, 1985·The Journal of Clinical Investigation·H Ishii, P W Majerus
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C T Esmon, W G Owen
Jan 1, 1982·European Journal of Nuclear Medicine·W N TauxeL R Smith
Dec 1, 1993·Thrombosis Research·O HergesellS Gabath
Jul 1, 2006·Stroke; a Journal of Cerebral Circulation·Jan T KielsteinStefanie M Bode-Böger

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Citations

Apr 20, 2004·International Journal of Cardiology·Sagar N DoshiJonathan Goodfellow
Nov 11, 2003·Trends in Pharmacological Sciences·James A Huntington, Trevor P Baglin
Nov 15, 2002·Thrombosis Research·Hansjörg ThudeDagmar Barz
Jun 24, 2003·Thrombosis Research·Jack Hirsh
Dec 16, 1998·Thrombosis Research·L WangB V Zlokovic
Feb 28, 2004·Trends in Cardiovascular Medicine·E Di Cera
Jun 6, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·Joanne Said, Gustaaf Dekker

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