Plasma total homocysteine levels in hyperthyroid and hypothyroid patients

Metabolism: Clinical and Experimental
B G NedrebøE A Lien

Abstract

We found a higher plasma concentration of total homocysteine (tHcy), an independent risk factor for cardiovascular disease, in patients with hypothyroidism (mean, 16.3 micromol/L; 95% confidence interval [CI], 14.7 to 17.9 micromol/L) than in healthy controls (mean, 10.5 micromol/L; 95% CI, 10.1 to 10.9 micromol/L). The tHcy level of hyperthyroid patients did not differ significantly from that of the controls. Serum creatinine was higher in hypothyroid patients and lower in hyperthyroid patients than in controls, whereas serum folate was higher in hyperthyroid patients compared with the two other groups. In multivariate analysis, these differences did not explain the higher tHcy concentration in hypothyroidism. We confirmed the observation of elevated serum cholesterol in hypothyroidism, which together with the hyperhomocysteinemia may contribute to an accelerated atherogenesis in these patients.

References

Jun 1, 1975·Metabolism: Clinical and Experimental·S H Mudd, J R Poole
Aug 1, 1989·American Journal of Hematology·H C FordM A Rendle
Feb 1, 1986·The American Journal of Clinical Nutrition·Y IngenbleekH Dirren
Mar 1, 1971·The American Journal of Medicine·V A Discala, M J Kinney
Feb 1, 1968·Annals of Internal Medicine·A D Steinberg
Nov 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R H AllenJ Lindenbaum
Aug 1, 1995·International Journal of Epidemiology·E ArnesenJ E Nordrehaug
Feb 1, 1996·Scandinavian Journal of Clinical and Laboratory Investigation·M ArnadottirH Thysell
Aug 1, 1997·Kidney International·A B GuttormsenH Refsum
Jan 1, 1953·Acta Medica Scandinavica·H MALMROS, B SWAHN
May 1, 1990·The Journal of Nutritional Biochemistry·J D Finkelstein
Nov 1, 1939·The Journal of Clinical Investigation·E F GildeaJ P Peters

❮ Previous
Next ❯

Citations

Dec 16, 1998·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·K Prasad
Feb 12, 2002·Lipids·M Cattaneo
Nov 14, 2000·The American Journal of Cardiology·W F BremnerL E Scheving
Sep 2, 1999·Advances in Enzyme Regulation·J D HouseJ T Brosnan
Feb 6, 2002·Nutrition·Yves IngenbleekLouis Jung
Feb 24, 2001·Clinical Endocrinology·M J DiekmanW M Wiersinga
Dec 3, 1999·Journal of Internal Medicine·O NygårdP M Ueland
Dec 1, 2004·Nutrition Research Reviews·Yves Ingenbleek, Vernon R Young
Jul 5, 2002·Thyroid : Official Journal of the American Thyroid Association·Rafael LuboshitzkyLena Lavie
Sep 13, 2002·Thyroid : Official Journal of the American Thyroid Association·Robert Deicher, Heinrich Vierhapper
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Harpal S Randeva
Sep 29, 2007·Thyroid : Official Journal of the American Thyroid Association·Leonidas H Duntas, Leonard Wartofsky
Dec 30, 1998·Current Opinion in Lipidology·H Refsum, P M Ueland
Jul 27, 2011·Journal of Lipids·Melpomeni PeppaGeorge Dimitriadis
Apr 17, 2012·International Journal of Endocrinology·Mehmet GunduzMesut Ozkaya
Oct 8, 2009·Vascular Medicine·Farhan J Khawaja, Iftikhar J Kullo
Apr 28, 2007·Endocrine Journal·Anna Orzechowska-PawilojcAnna Babinska
Oct 11, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·M BicíkováJ Tomandl
May 10, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Anna L BergMargret Arnadottir
Jan 13, 2004·Journal of Pediatric Endocrinology & Metabolism : JPEM·M Emre AtabekIbrahim Erkul
Oct 30, 2004·Treatments in Endocrinology·Vincenzo De LeoFelice Petraglia
Oct 8, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·L J Langman, D E Cole
Jun 22, 2012·Medicina clínica·Emilio Pariente RodrigoDaniel Nan Nan
Feb 12, 2005·Mayo Clinic Proceedings·Iftikhar J Kullo, Christie M Ballantyne
Sep 2, 2008·International Journal of Radiation Oncology, Biology, Physics·Ingvild VistadLars Mørkrid
Sep 21, 2006·Clinical Endocrinology·Alev E AltinovaMetin Arslan
Mar 17, 2005·Life Sciences·Paulo José Forcina MartinsVânia D'Almeida
Mar 31, 2005·Metabolism: Clinical and Experimental·Kathleen M ColleranMark R Burge
Dec 18, 2003·Clinical Cardiology·Gregory M GauthierPatrick E McBride
Mar 9, 2004·Endocrine Journal·Berrin DemirbasYalçin Aral
Feb 22, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe StellaJean-Louis Guéant
Sep 28, 2006·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Shon Meek, Robert C Smallridge
Mar 12, 2005·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Saleh AldasouqiAmal Merdad
Oct 29, 2002·Diabetes Care·Allon N FriedmanUNKNOWN Collaborative Study Group
Mar 9, 2005·American Journal of Hypertension·Arduino A MangoniStephen H D Jackson
Nov 10, 2006·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Yehuda G Assaraf
Feb 24, 2009·Sleep Medicine·Rogerio Santos-SilvaLia Rita A Bittencourt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.