PMID: 11915936Mar 28, 2002Paper

Plasma triglyceride metabolism in humans and rats during aging and physical inactivity

International Journal of Sport Nutrition and Exercise Metabolism
M T HamiltonL Bey

Abstract

Physical activity often declines with age because of a reduction in the spontaneous activities of daily living and because of less intense exercise. In controlled studies of young rats, it was shown that physical activities associated with walking and standing were especially important for maintaining a high level of lipoprotein lipase (LPL) activity in postural skeletal muscles (slow-twitch oxidative muscles). More intense contractions during run training were important for a high LPL activity in the fast-twitch glycolytic muscles. Aging also causes a fiber type-specific decrease of skeletal muscle LPL activity and LPL protein in weight-bearing skeletal muscles (and no aging effect in glycolytic muscles). Thus, contractile inactivity may be a significant factor causing sub-optimal triglyceride metabolism in skeletal muscles during both unloading in young animals and aging. Measurements of plasma LPL activity, plasma triglyceride (TG) clearance rates, postprandial hypertriglyceridemia after oral fat tolerance tests, and fasting TG levels were generally indicative of reduced plasma TG metabolism during middle or old age. In contrast, older endurance-trained individuals had a favorable blood lipid profile compared to age-matched ...Continue Reading

Citations

May 22, 2013·International Journal of Endocrinology·Kunihiro Sakuma, Akihiko Yamaguchi
Nov 13, 2004·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·James R Turk, M Harold Laughlin
Oct 29, 2009·Endocrine Reviews·Ines Pagel-LangenickelMichael N Sack
Oct 31, 2006·World Journal of Gastroenterology : WJG·Toshihito KosakaTakahiko Katoh
Apr 17, 2009·Pituitary·José Alexandre Curiacos de Almeida LemeEliete Luciano
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